Computational biology involves the analysis and discovery of biological phenomena using computational tools, and the algorithmic design and analysis of such tools. The field is widely defined and includes foundations in computer science, applied mathematics, statistics, biochemistry, molecular biology, genetics, ecology, evolution, anatomy, neuroscience, and visualization.
Students may pursue a Bachelor of Arts or a Bachelor of Science. Students pursuing the ScB have the option of electing a concentration in Computational Biology with one of three focus areas: Computer Sciences, Biological Sciences, or Applied Mathematics & Statistics. Both programs require a senior capstone experience that pairs students and faculty in creative research collaborations.
Standard program for the A.B. degree
Please see the bottom of the page for more information regarding the University Writing Requirement, the Capstone Experience, and the Computational Biology Honors Program.
Standard program for the A.B. degree
Please review the footnotes for clarifying details and see the bottom of the page for more information regarding the Capstone Experience and the Computational Biology Honors Program.
| Prerequisites (0-3 courses) | ||
| Students must complete or place out of these prerequisites. | ||
| Single Variable Calculus, Part II | ||
or MATH 0170 | Single Variable Calculus, Part II (Accelerated) | |
| Linear Algebra and Multivariable Calculus for Applied Mathematicians 1 | ||
or MATH 0180 | Multivariable Calculus | |
or MATH 0200 | Multivariable Calculus (Physics/Engineering) | |
or MATH 0350 | Multivariable Calculus With Theory | |
| The Foundation of Living Systems | ||
| General Core Requirements: Biology | 2 | |
| Genetics | ||
| Biochemistry | ||
or BIOL 0500 | Cell and Molecular Biology | |
| General Core Requirements: Chemistry | 1 | |
| Equilibrium, Rate, and Structure | ||
or CHEM 0350 | Organic Chemistry I | |
| General Core Requirements: Computer Science | 2 | |
| Choose one of the following groupings of introductory courses: | ||
Group A | ||
| Computing Foundations: Data and Program Design with Data Structures and Algorithms | ||
Group B | ||
| Introduction to Object-Oriented Programming and Computer Science and Program Design with Data Structures and Algorithms | ||
Group C | ||
| Computer Science: An Integrated Introduction and Program Design with Data Structures and Algorithms | ||
Group D | ||
| Accelerated Introduction to Computer Science and Program Design with Data Structures and Algorithms (or any full-credit computer science course above CSCI 0190) | ||
| General Core Requirements: Probability & Statistics 2 | 1 | |
| Introduction to Probability and Statistics with Calculus | ||
or APMA 1655 | Introduction to Probability and Statistics with Theory | |
or CSCI 1450 | Advanced Introduction to Probability for Computing and Data Science | |
or MATH 1210 | Probability | |
| Comp Bio Core Course Requirements | 4 | |
| Computational Molecular Biology | ||
| Inference in Genomics and Molecular Biology 2 | ||
AND two of the following: | ||
| Quantitative Models of Biological Systems | ||
| Statistical Inference II | ||
| Computational Probability and Statistics | ||
| Current Topics in Functional Genomics | ||
| Foundations of Population Genetics | ||
| Computational Methods for Studying Demographic History with Molecular Data | ||
| Pathogenomics: Analysis, interpretation and applications of microbial genomes | ||
| Human Genetics and Genomics | ||
| Methods in Informatics and Data Science for Health | ||
| Evaluation of Health Information Systems | ||
| Machine Learning | ||
| Deep Learning | ||
| Algorithmic Foundations of Computational Biology | ||
| Principles of Biostatistics and Data Analysis | ||
| Using R for Data Analysis | ||
Additional 1000+ level course with concentration advisor approval | ||
| Capstone Experience | 1 | |
Students enrolled in the computational biology concentration will complete a research project in their senior year under faculty supervision (i.e: BIOL 1950/1960, CSCI 1970, APMA 1970). The themes of such projects evolve with the field and the technology, but should represent a synthesis of the various specialties of the program. The requirements are either one semester of reading and research with a CCMB Faculty member or approved advisor resulting in an advanced research project or a 2000-level Computational Biology course that covers an advanced topic within the Computational Biology field and includes an advanced research component. 3 | ||
| Total Credits | 11 | |
- 1
These courses are prerequisites for APMA 1655. Students who matriculate in or after Fall 2025 will be required to take APMA 1655 as a prerequisite for APMA 1080 and will therefore need to complete or place out of one of these courses.
- 2
APMA 1655 will be a prerequisite for APMA 1080 starting in Fall 2025. Current concentrators (as of Spring 2025) may still take APMA 1080 with APMA 1650 as their prerequisite but APMA 1655 is encouraged. Students matriculating in Fall 2025 or later will need to take APMA 1655 before taking APMA 1080.
- 3
Some 2000-level courses are not available to undergraduate students due to department restrictions but have 1000-level equivalents (such as BIOL 1545/2545) that can count for capstone credit with approval from the instructor and the student's faculty advisor. Please reach out to the CCMB Academic Programs Coordinator for more information.
Capstone Experience:
Students enrolled in the computational biology concentration will complete a research project in their senior year under faculty supervision. The themes of such projects evolve with the field and the technology, but should represent a synthesis of the various specialties of the program. The requirements are either one semester of reading and research with a CCMB Faculty member or approved advisor, or a 2000-level Computational Biology course.
Honors:
In order to be considered a candidate for honors, students will be expected to maintain an outstanding record. Students must have a majority of either As or S with distinction grades in concentration courses. In addition, students should take at least one semester, and are strongly encouraged to take 2 semesters semesters, of reading and research with a CCMB faculty member or approved advisor. In addition, students should take at least one semester, and are strongly encouraged to take 2 semesters of reading and research with a CCMB faculty member or approved advisor.
Students seeking honors are advised to choose a Thesis Advisor prior to the end of their Junior year. Students must complete the Comp Bio Honors Registration form and submit their honors proposal to ccmb@brown.edu by the first Friday in October of their senior year. Students must submit a honors thesis in April of their senior year and present a public defense of their theses to the CCMB community. More information about the honors guidelines and deadlines can be found here: https://ccmb.brown.edu/academics/undergraduate-program/honors-designation. Any deviation from these rules must be approved by the director of undergraduate studies, in consultation with the student's advisor.
Standard program for the Sc.B. degree
Please see the bottom of the page for more information regarding the University Writing Requirement, the Capstone Experience, and the Computational Biology Honors Program.
Standard program for the Sc.B. degree
Please review the footnotes for clarifying details and see the bottom of the page for more information regarding the Capstone Experience and the Computational Biology Honors Program.
| Prerequisites (0-3 courses) | ||
| Students must complete or place out of these prerequisites. | ||
| Single Variable Calculus, Part II (or equivalent) | ||
or MATH 0170 | Single Variable Calculus, Part II (Accelerated) | |
| Linear Algebra and Multivariable Calculus for Applied Mathematicians 1 | ||
or MATH 0180 | Multivariable Calculus | |
or MATH 0200 | Multivariable Calculus (Physics/Engineering) | |
or MATH 0350 | Multivariable Calculus With Theory | |
| The Foundation of Living Systems (or equivalent) | ||
| General Core Course Requirements: Biology | 2 | |
| Genetics (prerequisite BIOL 0200 or equivalent) | ||
| Biochemistry | ||
or BIOL 0500 | Cell and Molecular Biology | |
| General Core Requirements: Chemistry | 1 | |
| Equilibrium, Rate, and Structure | ||
or CHEM 0350 | Organic Chemistry I | |
| General Core Requirements: Computer Science | 3 | |
| Introduction to Discrete Structures and Probability | ||
| AND complete one of the following groupings of introductory courses: | ||
| Group A | ||
| Computing Foundations: Data and Program Design with Data Structures and Algorithms | ||
| Group B | ||
| Introduction to Object-Oriented Programming and Computer Science and Program Design with Data Structures and Algorithms | ||
| Group C | ||
| Computer Science: An Integrated Introduction and Program Design with Data Structures and Algorithms | ||
| Group D | ||
| Accelerated Introduction to Computer Science and Program Design with Data Structures and Algorithms (or any full-credit computer science course above CSCI 0190) | ||
| General Core Requirements: Probability & Statistics 2 | 1 | |
| Introduction to Probability and Statistics with Calculus | ||
or APMA 1655 | Introduction to Probability and Statistics with Theory | |
or CSCI 1450 | Advanced Introduction to Probability for Computing and Data Science | |
or MATH 1210 | Probability | |
| General Core Requirements: Computational Biology | 2 | |
| Inference in Genomics and Molecular Biology 2 | ||
| Computational Molecular Biology | ||
| Six Courses in One Track | 6 | |
Choose one of 3 tracks: Computer Science, Biological Sciences, or Applied Mathematics and Statistics. See track requirements below. | ||
| Capstone Experience | 1 | |
Students enrolled in the computational biology concentration will complete a research project in their senior year under faculty supervision (i.e: BIOL 1950/1960, CSCI 1970, APMA 1970). The themes of such projects evolve with the field and the technology, but should represent a synthesis of the various specialties of the program. The requirements are either one semester of reading and research with a CCMB Faculty member or approved advisor resulting in an advanced research project or a 2000-level Computational Biology course that covers an advanced topic within the Computational Biology field and includes an advanced research component. 3 | ||
| Total Credits | 16 | |
- 1
These courses are prerequisites for APMA 1655. Students who matriculate in or after Fall 2025 will be required to take APMA 1655 as a prerequisite for APMA 1080 and will therefore need to complete or place out of one of these courses.
- 2
APMA 1655 will be a prerequisite for APMA 1080 starting in Fall 2025. Current concentrators (as of Spring 2025) may still take APMA 1080 with APMA 1650 as their prerequisite but APMA 1655 is encouraged. Students matriculating in Fall 2025 or later will need to take APMA 1655 before taking APMA 1080.
- 3
Some 2000-level courses are not available to undergraduate students due to department restrictions but have 1000-level equivalents (such as BIOL 1545/2545) that can count for capstone credit with approval from the instructor and the student's faculty advisor. Please reach out to the CCMB Academic Programs Coordinator for more information.
Tracks
Please review the prerequisites required for the courses below in CAB. Students should also be aware of the requirements for enrolling in a given CSCI course, which can be found on the Computer Science website.
| Computer Science Track: | ||
| Three of the following: | 3 | |
| Introduction to Computer Graphics | ||
| Database Management Systems | ||
| Foundations of AI | ||
| Machine Learning | ||
| Computer Vision | ||
| Deep Learning | ||
| Algorithmic Foundations of Computational Biology | ||
| Deep Learning in Genomics | ||
or other 1000+ level Computer Science course approved by the concentration advisor. | ||
| Three of the following: | 3 | |
| Quantitative Models of Biological Systems | ||
| Statistical Inference II | ||
| Computational Probability and Statistics | ||
| Foundations of Population Genetics | ||
| Computational Methods for Studying Demographic History with Molecular Data | ||
| Methods in Informatics and Data Science for Health | ||
| Computational Cognitive Neuroscience | ||
| Introduction to Software Engineering and Introduction to Computer Systems 1 | ||
| Probabilistic Methods in Computer Science | ||
| Design and Analysis of Algorithms | ||
| Principles of Biostatistics and Data Analysis | ||
| Using R for Data Analysis | ||
or another 1000+ level computational course approved by the concentration advisor. | ||
| Total Credits | 6 | |
- 1
Both CSCI 0320 and CSCI 0330 need to be taken to fulfill one of the six course requirements in this track.
| Biological Sciences track | ||
| At least four 1000+ level courses comprising a coherent theme related to Computational Biology. Examples of themes include: Biochemistry, Ecology, Evolution, Genomics, Immunology, or Neurobiology. Other themes can be approved by your concentration advisor. | 4 | |
| AND two courses from the following: | 2 | |
| Statistical Inference II | ||
| Computational Probability and Statistics | ||
| Current Topics in Functional Genomics | ||
| Host-microbiome Interactions in Health and Disease | ||
| Foundations of Population Genetics | ||
| Computational Methods for Studying Demographic History with Molecular Data | ||
| Pathogenomics: Analysis, interpretation and applications of microbial genomes | ||
| Machine Learning | ||
| Deep Learning | ||
| Algorithmic Foundations of Computational Biology | ||
| Using R for Data Analysis | ||
or other 1000+ level Computational Biology course approved by concentration advisor. | ||
| Total Credits | 6 | |
| Applied Mathematics & Statistics Track: | ||
| At least three courses from the following: | 3 | |
| Statistical Inference II | ||
| Computational Probability and Statistics | ||
| Artificial Intelligence | ||
| Methods of Applied Mathematics I and Methods of Applied Mathematics II | ||
| Applied Ordinary Differential Equations and Applied Partial Differential Equations I | ||
| At least three of the following: | 3 | |
| Quantitative Models of Biological Systems | ||
| Foundations of Population Genetics | ||
| Computational Methods for Studying Demographic History with Molecular Data | ||
| Human Population Genomics | ||
| Machine Learning | ||
| Deep Learning | ||
| Algorithmic Foundations of Computational Biology | ||
| Statistical Methods in Bioinformatics, I | ||
| Total Credits | 6 | |
Capstone Experience:
Students enrolled in the computational biology concentration will complete a research project in their senior year under faculty supervision. The themes of such projects evolve with the field and the technology, but should represent a synthesis of the various specialties of the program. The requirements are either one semester of reading and research with a CCMB Faculty member or approved advisor, or a 2000-level Computational Biology course.
Honors:
Honors:
In order to be considered a candidate for honors, students will be expected to maintain an outstanding record. Students must have a majority of either As or S with distinction grades in concentration courses. In addition, students should take at least one semester, and are strongly encouraged to take 2 semesters semesters, of reading and research with a CCMB faculty member or approved advisor. In addition, students should take at least one semester, and are strongly encouraged to take 2 semesters of reading and research with a CCMB faculty member or approved advisor.
Students seeking honors are advised to choose a Thesis Advisor prior to the end of their Junior year. Students must complete the Comp Bio Honors Registration form and submit their honors proposal to ccmb@brown.edu by the first Friday in October of their senior year. Students must submit a honors thesis in April of their senior year and present a public defense of their theses to the CCMB community. More information about the honors guidelines and deadlines can be found here: https://ccmb.brown.edu/academics/undergraduate-program/honors-designation. Any deviation from these rules must be approved by the director of undergraduate studies, in consultation with the student's advisor.