The Applied Math - Biology concentration recognizes that mathematics is essential to address many modern biological problems in the post genomic era. Specifically, high throughput technologies have rendered vast new biological data sets that require novel analytical skills for the most basic analyses. These technologies are spawning a new "data-driven" paradigm in the biological sciences and the fields of bioinformatics and systems biology. The foundations of these new fields are inherently mathematical, with a focus on probability, statistical inference, and systems dynamics. These mathematical methods apply very broadly in many biological fields including some like population growth, spread of disease, that predate the genomics revolution. Nevertheless, the application of these methods in areas of biology from molecular genetics to evolutionary biology has grown very rapidly in with the availability of vast amounts of genomic sequence data. Required coursework in this program aims at ensuring expertise in mathematical and statistical sciences, and their application in biology. The students will focus in particular areas of biology. The program culminates in a senior capstone experience that pairs student and faculty in creative research collaborations.
Standard program for the Sc.B. degree
Required coursework in this program aims at ensuring expertise in mathematical and statistical sciences, and their application in biology. The students will focus in particular areas of biology. The program culminates in a senior capstone experience that pairs student and faculty in creative research collaborations. Applied Math – Biology concentrators are prepared for careers in medicine, public health, industry and academic research.
Required Courses:
Students are required to take all of the following courses.
| MATH 0090 | Introductory Calculus, Part I | 1 |
| MATH 0100 | Introductory Calculus, Part II | 1 |
| or MATH 0170 | Advanced Placement Calculus | |
| MATH 0180 | Intermediate Calculus (or equivalent placement) | 1 |
| MATH 0520 | Linear Algebra | 1 |
| or MATH 0540 | Honors Linear Algebra | |
| CHEM 0330 | Equilibrium, Rate, and Structure 1 | 1 |
| PHYS 0030 | Basic Physics A | 1 |
| or PHYS 0050 | Foundations of Mechanics | |
| Select one of the following sequences: | 2 | |
| Applied Ordinary Differential Equations and Applied Partial Differential Equations I | ||
| Methods of Applied Mathematics I, II and Methods of Applied Mathematics I, II | ||
| APMA 1650 | Statistical Inference I | 1 |
| or APMA 1655 | Statistical Inference I | |
| APMA 1070 | Quantitative Models of Biological Systems | 1 |
| APMA 1080 | Inference in Genomics and Molecular Biology | 1 |
| or NEUR 2110 | Statistical Neuroscience | |
| BIOL 0200 | The Foundation of Living Systems (or equivalent) | 1 |
| Additional Courses | ||
| One additional course in Applied Math or Biology | 1 | |
| We strongly recommend that Applied Mathematics-Biology concentrators take one of the programming courses on or before their first semester as a concentrator. Those who do can use it to satisfy this requirement: | ||
| Introduction to Scientific Computing | ||
| Introduction to Scientific Computing and Problem Solving | ||
| Computing Foundations: Data | ||
| Introduction to Object-Oriented Programming and Computer Science | ||
| Computer Science: An Integrated Introduction | ||
| Accelerated Introduction to Computer Science | ||
| Introduction to programming | ||
| One research-related course in Applied Math or Biology. For example: | 1 | |
A senior seminar course from the APMA 193X, 194X series | ||
A directed research/independent study course in a related discipline (i.e. STEM disciplines, ENVS, PHP, etc.) if the project is relevant to the student's learning goals in the concentration and with approval from the concentration advisor. | ||
A non-research course related to the concentration along with a research experience equivalent in scope and scale to work the student would pursue in an Applied Math or Biology independent study course. Examples include UTRAs, LINK awards, research programs at other institutions, etc. This requires approval from the concentration advisor and appropriate documentation. | ||
Other equivalent opportunities not listed - with approval from the concentration advisor. | ||
| Four classes in the biological sciences agreed upon by the student and advisor. These four courses should form a cohesive grouping in a specific area of emphasis, at least two of which should be at the 1000-level. Some example groupings are below: | 4 | |
| Areas of Emphasis and Suggested Courses: | ||
| Some areas of possible emphasis for focusing of elective courses are listed below. Given the large number of course offerings in the biosciences and neuroscience, students are free to explore classes in these areas that are not listed below. However, all classes must be approved by the concentration advisor. APMA 1910 cannot be used as an elective. | ||
Biochemistry | ||
| Biochemistry | ||
| Advanced Biochemistry | ||
| Organic Chemistry | ||
| Chemical Biology | ||
Biotechnology and Physiology | ||
| Principles of Physiology | ||
| Cell Physiology and Biophysics | ||
and/or appropriate bioengineering courses, such as: | ||
| Polymer Science for Biomaterials | ||
| Biomaterials | ||
| Tissue Engineering | ||
| Stem Cell Engineering | ||
| Synthetic Biological Systems | ||
Ecology, Evolution, and Genetics | ||
| Invertebrate Zoology and Evolutionary Biology | ||
| Principles of Ecology and The Evolution of Plant Diversity | ||
| Genetics | ||
| Experimental Design in Ecology | ||
| Population Genetics | ||
| Human Population Genomics | ||
| Molecular Genetics | ||
Neuroscience | ||
| Mathematical Methods in the Brain Sciences | ||
Neurosciences courses: See https://www.brown.edu/academics/neuroscience/undergraduate/neuroscience-concentration-requirements | ||
| Cell Physiology and Biophysics | ||
| Topics in Signal Transduction | ||
| Synaptic Transmission and Plasticity | ||
| Total Credits | 18 | |
| 1 | Students whose independent study is expected to be in an experimental field are strongly encouraged to take APMA 1660, which covers experimental design and the analysis of variance (ANOVA), a method commonly used in the analysis of experimental data. |
Honors
Requirements and Process: Honors in the Applied Math-Biology concentration is based primarily upon an in-depth, original research project carried out under the guidance of a Brown (and usually Applied Math or BioMed) affiliated faculty advisor. Projects must be conducted for no less than two full semesters, and students must register for two semesters of credit for the project via APMA 1970 or BIOL 1950/BIOL 1960 or similar independent study courses. One of these courses can be used to fulfill the research-related course requirement, but the other cannot be used elsewhere in the concentration. The project culminates in the writing of a thesis which is reviewed by the thesis advisor and a second reader. It is essential that the student have one advisor from the biological sciences and one in Applied Mathematics. The thesis work must be presented in the form of an oral presentation (arranged with the primary thesis advisor) or posted at the annual Undergraduate Research Day in either Applied Mathematics or Biology. For information on registering for BIOL 1950/BIOL 1960, please see https://www.brown.edu/academics/biology/undergraduate-education/undergraduate-research
Excellence in grades within the concentration as well as a satisfactory evaluation by the advsors are also required for Honors. The student's grades must place them within the upper 20% of their cohort, in accordance with the university policy on honors. Honors recipients typically maintain a Grade Point Average of 3.4 or higher in the concentration. However, in the case of outstanding independent research as demonstrated in the thesis and supported by the Thesis Committee, candidates with a GPA between 3.0 an 3.4 will be considered and are encouraged to apply.
The deadline for applying to graduate with honors in the concentration are the same as those of the biology concentrations. However, students in the joint concentration must inform the undergraduate chair in Applied Mathematics of their intention to apply for honors by these dates.