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Biology (Undergraduate)

The Undergraduate Program in Biology offers courses at all levels of biological organization: molecular, cellular, organismal and population, and concentration programs with varying degrees of multidisciplinary or specialty foci.

There is a vast range of collaborative opportunities for independent study and research under the mentorship of the faculty. Faculty maintain research programs at the cutting edge of their fields including biochemistry, biophysics, cell biology, developmental biology, ecology, evolution, genetics, immunology, molecular biology, neurobiology, physiology, anatomy, artificial organs, microbiology, virology, experimental pathology, and pharmacology. The close administrative relationship with the Alpert Medical School offers additional opportunities for blending fundamental biology and clinical sciences in research projects at the Brown-affiliated hospitals.

The Office of Biology Undergraduate Education is a full service academic resource center, serving a key role for students of the life sciences here. The Office provides individualized advising for students at all levels; oversees student- faculty research collaborations, holds special events and maintains a variety of programs that support and enrich student life.

For further information, please visit: http://www.brown.edu/academics/biology/undergraduate-education/

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BIOL 0030. Principles of Nutrition.

Introduces the basic principles of human nutrition, and the application of these principles to the specific needs of humans, and the role of nutrition in chronic diseases. Provides an overview of the nutrients and their use by the human body. Also examines the role of nutrients in specific functions and disease states of the body. Not for biology concentration credit. Enrollment limited to 100.

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BIOL 0040. Nutrition for Fitness and Physical Activity.

Reviews the role of nutrition in physical activity and health. It is designed to provide the student with the information and skills needed to translate nutrition and physical activity recommendations into guidelines for both the athlete for maximal performance and the non-athlete to improve both health and body weight. Students will learn the use of the energy yielding nutrition in physical activity and how food choices can influence both athletic performance and long-term health through the effect on risk factors for chronic diseases. Prerequisite: BIOL 0030. Enrollment limited to 20. Instructor permission required.

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BIOL 0060. Introduction to Human Physiology.

An introduction to human physiology aimed primarily at undergraduates who have minimal to no Biology background or who are not concentrating in biology. Acquire a basic understanding of the physiological mechanisms that allow for the running of each major organ systems. Topics include basic cardiovascular, respiratory, urinary, digestive, endocrine, and neuromuscular function, as well as aspects of reproduction and exercise physiology. Not for biology concentration credit. Lab.

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BIOL 0080. Biotechnology Management.

An examination of the pharmaceutical, biotechnology, and medical product industries: what they are, how they function, whence they originate, and various perspectives on why some succeed and others fail. Pathways from lab-bench to marketplace are described as are the pervasive influences of the FDA, patent office, and courts. Extensive reading; emphasis on oral presentation. Primarily intended for students planning a career in biomedical industry. Not for biology concentration credit. Enrollment limited to 20.

Spr BIOL0080 S01 25931 T 4:00-6:30(16) (B. Bready)
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BIOL 0100. Living Biology at Brown and Beyond.

BIOL0100 is a first year seminar designed for aspiring biology program students. The course introduces students to the people and opportunities in Brown’s Biology Program and fosters academic and soft skill development. Students will practice a range of laboratory methods used in molecular biology while examining the ways in which those methods are used in research and in the development of medical treatments. Students will hone their writing skills, learn to effectively read primary STEM literature, and consider how various disciplines in Biology come together to tackle critical global problems such as global environmental change and emerging infectious disease. BIOL 0100 is best suited for students with minimal experience in the biological sciences.

Spr BIOL0100 S01 20226 W 3:00-5:30(10) (K. Monteiro)
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BIOL 0110. Fake Math: Analyzing the Misuse of Quantitative Concepts.

From the Scarecrow in the Wizard of Oz to the White House, quantitative errors are made and put forth. This course will present, discuss, and challenge students to analyze misused quantitative concepts. These errors will be taken from misapplied logic; inappropriate use of numbers; graphical inaccuracies and manipulations; cognitive illusions; self-fulfilling prophecies; the wrong-but-often-relied-upon Law of Small Numbers; conditional probability; correlation, confounding, and causality; hazards of data mining; circular reasoning; and basic misuses of statistics. Introductory concepts of classical logic, probability, and statistics will be presented and reviewed, and examples of their misuse will be discussed and evaluated.

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BIOL 0140B. Communicating Science: Biological Illustration.

This Sophomore Seminar is an immersion practicum that conjoins art and science. Employing a series of techniques, students will learn the protocols of scientific rendering in an intensive hands-on approach. Field trips will include the RISD Nature Lab, the Brown Greenhouse, and John Hay collection of biomedical and botanical folios. Media will include graphite/ carbon dust; pen and ink (stipple, line); coquille board; scratch-board, colored pencil, watercolor and polymer clay. Course will be driven by project presentations focused on communicating science through illustration. Not for concentration credit in Biological Sciences programs. Instructor permission required; enrollment 10 students. 1/2 credit.

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BIOL 0140K. Conservation Medicine.

How have fruit bats contributed to the emergence of Nipah virus in Malaysia? Is an infectious cancer going to drive the Tasmanian Devil to extinction? Will a warmer world be a sicker world? We will consider these and additional topics at the intersection of global change biology and infectious disease emergence in this course. The course should be of interest to pre-med, general biology and environmental studies concentrators seeking interdisciplinary learning classroom experience. This will satisfy "Area 3" organismal biology concentration requirement for Biology/Health-Human Biology. Expected background: BIOL 0200 or equivalent placement. Enrollment limited to 12 sophomores. Instructor permission required.

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BIOL 0140T. Communicating Science Through Visual Media.

This class, offered jointly by professors at RISD and Brown, will explore the pedagogy and practice of using visual media to convey scientific concepts. The goal of this course will be to assess examples of existing material and create new animations/video that fill an educational need and make science engaging and accessible. Class time will be comprised of lectures, labs, screenings, discussions, critiques and exercises. After an introduction to teaching pedagogy and the basics of animation and visual design, small student teams will be paired with science faculty mentors to create videos and animations that explain scientific concepts.

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BIOL 0150A. Techniques and Analyses using DNA-Based Biotechnology.

Students will study and practice a range of methods used in molecular biology while examining the ways in which those tools are used in research and in the development of medical treatments. This experience, combined with the reading and discussion of selected papers from the primary literature, fosters development of a skill set critically important for the modern day biology student. Expected background: high school Biology course. Enrollment limited to 10 first year students. Instructor permission required. Half-credit course. S/NC.

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BIOL 0150B. Statistical Computing for Biology.

Modern biological research is a data rich endeavor, necessitating strong quantitative and computational skills to interpret the results of experimental and observational studies. In this course we will explore the application of statistics and modeling in biological research and environmental science. Topics covered will include basic probability, experimental design, sampling, hypothesis testing and mathematical models for prediction. No prior statistics knowledge is assumed. Enrollment limited to 10 first year and sophomore students. Instructor permission, based on a portfolio review. This is a half-credit course. S/NC

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BIOL 0150C. Introduction to Ethnopharmacology.

Plant secondary metabolites are currently the subject of much research interest when investigating new target compounds for potential medicine from natural products. New leads for drugs and phytomedicines from plants and plant parts have been increasing at a rapid rate especially by the pharmaceutical industry. Many plants have been selected and collected for their specific secondary compounds and healing powers by ethnobotanists in the field. Students will gain hands on experience identifying medicinal plants, laboratory equipment, sampling procedures, field tests and extraction techniques of secondary metabolites by high throughput screening methods. Enrollment limited to 10 FYS. Instructor permission required.

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BIOL 0150D. Techniques in Regenerative Medicine: Cells, Scaffolds and Staining.

Regenerative Medicine, also known as Tissue Engineering, is the process of creating living, functional tissues to repair or replace native tissue or organ functions that have been lost due to disease or congenital defects. As such, it is a prominent scientific discipline that can either "stand alone" or complement material-based research efforts in the areas of device design, drug delivery, diagnostics and pharmaceuticals. Students will develop proficiencies in basic cell culture techniques, early stage tissue regeneration strategies and histochemical characterization of mammalian cell constructs. Enrollment limited to 10 first year students. Instructor permission required. Half-credit course. S/NC.

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BIOL 0160. Plants, Food, and People.

Examines the selection, breeding, cultivation and uses of food plants. Discusses the effects on agriculture of pathogens, climate change, and loss of biodiversity. Considers whether enough food can be produced for a world population of potentially 10 billion, while sustaining biodiversity and environmental quality. Enrollment limited to 50.

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BIOL 0170. Biotechnology in Medicine.

Introduces undergraduates to the main technological advances currently dominating the practice of medicine. Provides an overview of the objectives, techniques, and problems related to the application of biomedical technology to the diagnosis and treatment of disease and the contemporary health care industry. Topics include: pharmaceutical development and formulation; organ replacement by prosthesis and transplantation; medical imaging; tissue engineering, therapeutic cloning, regenerative medicine; stem cells; societal, economic, and ethical issues. This course does carry Biology concentration credit.

Fall BIOL0170 S03 17803 MWF 1:00-1:50(08) (T. Achilli)
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BIOL 0180. The Biology of AIDS.

AIDS represents an example of the vulnerability of humans to new infectious agents. We will review some human infectious diseases including small pox yellow fever and influenza, and then explore AIDS/HIV. First characterized in 1981, AIDS became the leading cause of death in U.S. males aged 25-44 within a decade. We will examine what factors make HIV such a potent pathogen. The course is intended for students beginning in biology. Expected: BIOL 0200, or equivalent placement. This course does carry Biology concentration credit.

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BIOL 0190E. Botanical Roots of Modern Medicine.

This course will explore a variety of medicinal plants found throughout the world, the diverse cultures that use them in their daily lives and the scientific underpinnings of their medicinal uses. In conjunction with readings, students will gain a hands-on approach in lab, observing, identifying and growing these plants. Enrollment limited to 19. Students MUST register for the lecture section and the lab.

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BIOL 0190F. Darwinian Medicine.

Explores evolutionary explanations of why we get sick, and how this can shape, or misshape, our interpretations of medicine. Draws on evolutionary genetics, population biology, molecular biology and physiology. This course will build on evolutionary biology and then focus on disease processes such as infection, aging, cancer, allergy, diabetes, and obesity. Enrollment limited to 19 first year students.

Fall BIOL0190F S01 10285 TTh 1:00-2:20(06) (M. Tatar)
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BIOL 0190P. Pride and Prejudice in the Development of Scientific Theories.

We will examine how the pace and shape of scientific progress is affected by the social/cultural context and the "personality" of the individual. We will look into how the interplay between society and the individual affects how scientific theories arise, are presented, are debated and are accepted. The course will initially focus on Charles Darwin and his theory of Natural Selection using the biography of Adrian Desmond and James Moore, "Darwin: The Life of a Tormented Evolutionist." Enrollment limited to 19 first year students.

Fall BIOL0190P S01 10260 TTh 2:30-3:50(12) (S. Helfand)
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BIOL 0190Q. Climate Change and Species Extinction.

In this course students will go beyond the headlines and delve into the science to explore the impact of climate change on species extinction. Students will explore the integration of science and technology through traditional textbooks, primary literature, open source databases, simulations, and discussions. Students will investigate the impact of climate change on species distribution, ecology, and behavior through interactive, inquiry-based, collaborative classroom investigations. Students will learn to integrate information from a variety of sources and disciplines and share their ideas through classroom discussion, written assignments, and oral presentations. Enrollment limited to 19 first year students.

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BIOL 0190R. Phage Hunters, Part I.

A research-based lab class for freshmen; both semesters are required in the sequence. Students will isolate and characterize a bacteriophage viruses found in the soil. Lab work includes isolation and purification of your own phage, DNA isolation and restriction mapping, and EM characterization of your phage. Several phages will be selected for genome sequencing, and will be annotated during the second semester. Instructor permission required. Admittance based on review of applications in the first class. Limited to 19 freshmen.

Fall BIOL0190R S01 10246 T 4:00-6:30(07) (S. Taylor)
Fall BIOL0190R L01 16657 M 1:00-4:00 (S. Taylor)
Fall BIOL0190R L02 16658 W 1:00-4:00 (S. Taylor)
Fall BIOL0190R L03 16659 F 1:00-4:00 (S. Taylor)
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BIOL 0190S. Phage Hunters, Part II.

A research-based laboratory/class for freshmen; both semesters are required. Students will isolate and characterize a bacteriophage viruses found in the soil. Lab work includes isolation and purification of your own phage, DNA isolation and restriction mapping, and EM characterization of your phage. Several phages will be selected for genome sequencing over Winter Recess, and annotated in the spring. One hour of lecture/discussion, and 3 hours lab per week. Expected: AP Biology or equivalent, HS chemistry, and permission of the instructor. Students are expected to take fall and spring courses in the sequence. Enrollment limited to 19 first-year students. Instructor permission.

Spr BIOL0190S S01 20217 Th 4:00-6:30(16) (S. Taylor)
Spr BIOL0190S S01 20217 T 4:00-6:30(16) (S. Taylor)
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BIOL 0190T. Bioinformatics: A Practical Introduction.

The amount of biological sequence data has grown at an exponential pace and spurred the development of computational tools that allow biologists to use this information. Students will become familiar with useful bioinformatics tools used by researchers. The course will introduce concepts of information transfer in biological molecules, storage in public databases, and how to use tools to access this information and organize it meaningfully. We will explore tools for studying whole genomes, including high-throughput sequencing data to assemble genomes and mapping subsets. Students will gain hands-on experience using these tools. Expected: AP credit or equivalent placement for BIOL 0200.

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BIOL 0190U. The Lives of Plants.

This course examines the lives of plants through their development, structure, function, reproduction, and responses to environmental conditions. Enrollment limited to 19 first year students.

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BIOL 0200. The Foundation of Living Systems.

A broad overview of biological systems, emphasizing patterns and processes that form the basis of life. Explores essentials of biochemistry, molecular, and cellular biology and their relationship to the larger issues of ecology, evolution, and development. Examines current research trends in biology and their influence on culture. Appropriate for all students interested in biology. Serves as a gateway course to much of the intermediate and advanced curriculum. Placement tests are offered (contact Jody_Hall@brown.edu); AP scores of 4 or 5 are equivalent to BIOL 0200, and place a student out of this course. Students will be assigned to a lab time during the second week of class.

Fall BIOL0200 S01 10261 MWF 9:00-9:50(09) (W. Holmes)
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BIOL 0210. Diversity of Life.

This course will explore biological diversity – the number of taxa, and the functions, and processes that support life – from the perspectives of ecology and evolutionary biology. It will draw on examples and case studies from the geological record, functional morphology, the evolution of organ systems in vertebrates, genomics, behavior and sexual selection in birds and invertebrates. Overarching themes will emphasize that taxonomic diversity is an emergent property of complex life on Earth, and the importance of diversity of biological functions and processes in generating and maintaining taxonomic diversity. The course is open to all students.

Fall BIOL0210 S01 10286 MWF 11:00-11:50(16) (J. Kellner)
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BIOL 0280. Biochemistry.

Lectures and recitation sections explore the mechanisms involved in the principles of macromolecular structure and function, the organization and regulation of pathways for intermediary metabolism, and the transfer of information from genes to proteins. Expected background: Cell and Molecular Biology (BIOL 0500) or another intermediate level course providing background in molecular level thinking, e.g. BIOL 0470, BIOL 0530 or NEUR 1020.

Spr BIOL0280 S01 20227 TTh 1:00-2:20(08) (W. Holmes)
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BIOL 0285. Inquiry in Biochemistry: From Gene to Protein Function.

In this inquiry-based research course, students work in teams to formulate and test a hypothesis about how a change in genetic sequence affects enzyme function. Students will cultivate skills in scientific visualization, experimental design, data analysis, and laboratory techniques in molecular biology and biochemistry. In discussion, students will learn scientific writing through peer editing and iterative revisions to write a full scientific paper. This course is WRIT designated and will prepare students for writing an honors thesis. Expected: Students have previously taken or be concurrently enrolled in BIOL 0280. Enrollment in one lab section and one discussion section is required.

Spr BIOL0285 S01 20228 M 1:00-5:00 (A. Smith)
Spr BIOL0285 S02 20229 Th 2:30-6:30 (A. Smith)
Spr BIOL0285 C01 25619 T 4:00-5:00 (A. Smith)
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BIOL 0300. Endocrinology.

A basic examination of endocrinology with emphasis on hormone biosynthesis, mechanism of action, physiological roles, and endocrine pathology. Topics include: mechanism of action of steroid, amine, and peptide hormones; neuroendocrinology; reproductive endocrinology; and endocrinology of metabolism and calcium homeostasis. It is expected that students have taken BIOL 0200 (or equivalent) and CHEM 0350.

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BIOL 0320. Vertebrate Embryology.

Introduction to the developmental anatomy of vertebrate embryos, including humans, in an evolutionary context, through lecture, discussion and microscope slide study. Gametogenesis through germ layers and their organ system derivatives. Expected: BIOL 0200, or equivalent placement, or AP Biology score of 4 or 5. Limited to 18 freshmen and 18 sophomores. Students MUST register for the lecture section and the lab.

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BIOL 0350. The Fossil Record: Life through Time on Earth.

Course is designed for students with prior background in geology or evolutionary biology and who want to learn more about the fossil record, the origins of modern biodiversity and ecosystem structure, and interaction between organisms, and the geological and chemical cycles on the Earth. Lectures will cover major time periods during which animals and plants lived, as well as focusing on major transitions in the evolution of life on Earth. This course will fulfill requirements in both the geology/biology and evolutionary biology concentrations. Expected: BIOL 0210, GEOL 0240 or equivalent. Instructor permission, enrollment limited to 20 sophomores/juniors; register for course/lab.

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BIOL 0380. The Ecology and Evolution of Infectious Disease.

Infectious diseases remain among the leading causes of death worldwide, and this burden is disproportionately borne by children living in low- and middle-income countries. Thus management of infectious disease remains a critical intellectual challenge in the 21st century. This course will develop and apply ecological and evolutionary theory to infectious microbes (and their hosts) via the detailed examination of a number of case studies. This will be accomplished by a combination of lectures, discussions, and readings drawn mainly from the primary literature. Assessment will be based on biweekly problem sets, two midterms and one final exam. Expected: BIOL 0200, BIOL 0210 or equivalent.

Fall BIOL0380 S01 10287 MWF 10:00-10:50(14) 'To Be Arranged'
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BIOL 0390. Vertebrate Evolution and Diversity.

An overview of vertebrate evolution that not only covers historical events, but also introduces various scientific concepts and modes of thought. Topics include past and present biodiversity, convergent evolution, biogeography, competition, continental drift, climatic change over time, the notion of evolution as progress, and a whole-animal approach to understanding evolutionary events. Enrollment limited to 50.

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BIOL 0400. Biological Design: Structural Architecture of Organisms.

Many questions about the workings of living creatures can be answered by joining math, physics, and biology. We will identify basic physical science concepts that help biologists understand the structure and function of animals, plants, and microorganisms, and use these to study how the physical world constrains and facilitates the evolution of the extraordinary design and diversity of organisms. For first and second year students; others by permission. Recommended background: BIOL 0200, or equivalent. Enrollment limited to 40. Instructor permission required.

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BIOL 0410. Invertebrate Zoology.

A survey of invertebrate animals emphasizing evolutionary patterns and ecological relationships. Functional morphology, physiology, reproduction, development, and behavior of invertebrates will be examined. Laboratory exercises and two separate day-long field trips provide firsthand experience with the animals. Expected: BIOL 0200 or equivalent. Enrollment limited to 44. Students MUST register for the lecture section and a lab.

Fall BIOL0410 S01 10288 TTh 9:00-10:20(05) (P. Ewanchuk)
Fall BIOL0410 L01 16660 W 1:00-3:50 (P. Ewanchuk)
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BIOL 0415. Microbes in the Environment.

Examines the diversity of microbial life in the environment. Surveys key services that microbes perform on land and sea, including biodegradation of contaminants in the environment and ecosystem processes related to climate change. Examines biological interactions of symbioses, quorum sensing, and antibiotic production in a ecological context. Explores the genomic mechanisms explaining phylogeny and life history strategies in microbes. Demonstrate knowledge of the diversity of microbes in the environment and benefits in an ecological/evolutionary context. Lecture based, two fieldtrips to expand appreciation for microbial ecology. BIOL 0200 or equivalent placement; CHEM 0330. Enrollment limited to 20 sophomores, juniors and seniors.

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BIOL 0420. Principles of Ecology.

The principles, concepts, and controversies involved in the study of the distribution and abundance of plant and animal populations and their integration into natural communities. Emphasizes interactions among organisms and the hierarchical nature of ecological processes affecting individuals, populations, and communities. Expected: BIOL 0200 (or equivalent) and MATH 0090. Lectures and weekly discussion.

Spr BIOL0420 S01 20253 TTh 9:00-10:20(05) (J. Witman)
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BIOL 0430. The Evolution of Plant Diversity.

Examines the evolutionary history of plants from a phylogenetic perspective. Introduces the principles of phylogenetics and the use of phylogenies to understand organismal evolution. Highlights major trends in plant evolution over the past 400 million years. Lectures survey major plant lineages, with special focus on flowering plants. Weekly labs and assignments stress basic plant anatomy and morphology, identification, and learning to recognize and appreciate the abundance, diversity, and uses of plants in daily life. Expected: BIOL 0200 (or equivalent placement).

Spr BIOL0430 S01 20254 TTh 9:00-10:20(05) (R. Kartzinel)
Spr BIOL0430 L01 25729 Th 1:00-4:00 (R. Kartzinel)
Spr BIOL0430 L02 25730 F 1:00-4:00 (R. Kartzinel)
Spr BIOL0430 L03 25731 Arranged (R. Kartzinel)
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BIOL 0440. Inquiry in Plant Biology: Analysis of Plant Growth, Reproduction and Adaptive Responses.

This course focuses on what plants do and how they do it. Introduces the biology of plants, their growth and development, structural features, and their cellular and organismal responses to key stimuli. Examines physiological, reproductive and developmental strategies throughout the plant life cycle and in relation to environmental challenges. During laboratory section meetings, students pursue inquiry-based group research projects addressing novel questions about mechanisms that control plant growth and development. Laboratory section is required. Prerequisites: One Brown course with laboratory section in either Biology or Chemistry. Enrollment limited to 24 students.

Spr BIOL0440 S01 20230 Arranged (A. DeLong)
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BIOL 0450. Evolutionary Behavioral Ecology.

An exploration of the ecological and evolutionary principles that define animal behavior in the natural world. We will focus mostly on the field of behavioral ecology, including important phenomena like avoiding predators, obtaining food, finding mates, producing offspring, living in groups, and solving problems. In doing so, we will combine ideas and principles from the disciplines of ecology, systematics, physiology, and economics.

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BIOL 0455. Coastal Ecology and Conservation.

Will enable to students to master fundamental ecological concepts and understand how this knowledge can be used to inform coastal conservation and management. Case studies from New England and elsewhere, field trips to rocky shores, salt marshes and coastal ecosystems enable students to develop scientific skills and experience the challenges of coastal conservation science. The course is aimed at freshmen and sophomores. Expected background: BIOL 0200 or equivalent placement. Enrollment limited to 10 students, and written permission required. Email (Mark_Bertness@brown.edu) to receive course application (due May 1). Admitted students register for the course in September.

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BIOL 0460. Insect Biology.

Focuses on characteristics that make insects unique and why more insect species have been described than all other organisms combined; the opportunity to investigate diversity and adaptation; their abundance, small size, and short lifespans; their importance as agents of biocontrol pollination, agricultural pests, and disease vectors. Expected: BIOL 0200 or equivalent. Enrollment limited to 20. Students MUST register for lecture AND lab. Primarily for freshmen and sophomores.

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BIOL 0470. Genetics.

Genetic phenomena at the molecular, cellular, organismal, and population levels. Topics include transmission of genes and chromosomes, mutation, structure and regulation of the expression of the genetic material, elements of genetic engineering, and evolutionary genetics. One laboratory session and one discussion session per week. (Students should not plan to take BIOL 0470 after 1540.) Expected: BIOL 0200 (or equivalent placement). Students will be assigned to Lab sections the first week of class. If you plan to take BIOL 470 but are also considering registering for a course that conflicts with the BIOL 470 lecture period, you may be eligible to do so by enrolling in S02, an alternative section of BIOL 470. Enrollment in this section allows students asynchronous engagement with lectures which are recorded and posted to the course Canvas page at the end of each class period. In-person participation in laboratory meetings and exams, however, are still required.

Fall BIOL0470 S01 10262 TTh 10:30-11:50(13) (M. Johnson)
Fall BIOL0470 S02 10263 Arranged (M. Johnson)
Fall BIOL0470 S03 10264 Arranged (M. Johnson)
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BIOL 0480. Evolutionary Biology.

A broad introduction to the patterns and processes of evolution at diverse levels of biological organization. Topics covered include natural selection, adaptation, speciation, systematics, macroevolution, mass extinction events, and human evolution. Students will be given the opportunity to do their 23andMe ancestry analyses as a means of integrating the topics that span genomics to human variation. Weekly discussion sections involve active learning simulations and discussions of papers from the primary literature. Occasional problem sets involve computer exercises with population genetics and phylogeny reconstruction. Expected: BIOL 0200 (or equivalent placement).

Fall BIOL0480 S01 10289 MWF 9:00-9:50(09) (D. Rand)
Fall BIOL0480 S02 16661 Arranged (D. Rand)
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BIOL 0495. Statistical Analysis of Biological Data.

A first course in probability distributions and the use of statistical methods for biological data. Topics covered will include describing data, statistical inference (hypothesis tests and confidence intervals), analyzing associations, and methods for categorical data (contingency tables and odds ratios). Methods will be applied to data drawn from areas of biological inquiry. For statistics or related science credit in Biology programs. Expected background: BIOL 0200 or equivalent, math equivalent to MATH 0100. This course is for related science credit only in Biological Sciences concentration programs.

Spr BIOL0495 S01 20255 TTh 2:30-3:50(11) (S. Ramachandran)
Spr BIOL0495 C01 25735 M 6:00-8:00PM (S. Ramachandran)
Spr BIOL0495 C02 25736 T 8:00PM-10:00PM (S. Ramachandran)
Spr BIOL0495 C03 25737 W 6:00-8:00PM (S. Ramachandran)
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BIOL 0500. Cell and Molecular Biology.

This course examines the structure and function of the basic unit of an organism, the cell. An experimental approach is used to examine cellular functions, ranging from gene transcription, cell division and protein secretion, to cell motility, and signal transduction. Relevance to health and disease will be considered. Expected: BIOL 0200 (or equivalent advanced placement biology 4/5).

Spr BIOL0500 S01 20231 MW 3:00-4:20(10) (G. Valdez)
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BIOL 0510. Introductory Microbiology.

Introduces role of microbes in our understanding of biology at the cellular and molecular level. Focuses on microbial significance for infectious disease, public health, genetics, biotechnology, and biogeochemical cycles. Laboratory involves basic microbiological techniques and selection and manipulation of microbes. Expected: BIOL 0200 (or equivalent placement). Students MUST register for the lecture section, conference, and the lab. Enrollment limited to 108.

Spr BIOL0510 S01 20218 MW 8:30-9:50(02) (P. Belenky)
Spr BIOL0510 L01 25738 T 9:00-10:20 (A. Dugan)
Spr BIOL0510 L02 25739 T 10:30-11:50 (A. Dugan)
Spr BIOL0510 L03 25740 T 1:00-2:20 (A. Dugan)
Spr BIOL0510 L04 25741 T 2:30-3:50 (A. Dugan)
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BIOL 0530. Principles of Immunology.

Introduction to experimental and theoretical foundations of immunology. Focuses on concepts, landmark experiments and recent advances. Topics include innate and adaptive immunity; structure/function of antibody molecules and T cell receptors; regulation of immune responses through cellular interactions. Applications of concepts to medically significant issues (vaccines, transplantation, inflammation, autoimmunity, cancer, HIV/AIDS) are discussed. Interpretative analysis of experimental data is emphasized. Expected background: BIOL 0200 or equivalent placement credit.

Fall BIOL0530 S01 10247 TTh 2:30-3:50(12) (A. Dugan)
Fall BIOL0530 C01 16662 Su 2:00-2:50 (A. Dugan)
Fall BIOL0530 C02 16663 M 6:00-6:50 (A. Dugan)
Fall BIOL0530 C03 16664 M 7:00-7:50 (A. Dugan)
Fall BIOL0530 C04 16665 M 8:00PM-8:50PM (A. Dugan)
Fall BIOL0530 C05 16666 T 8:30PM-9:20PM (A. Dugan)
Fall BIOL0530 C06 16667 W 6:00-6:50 (A. Dugan)
Fall BIOL0530 C07 16668 W 7:00-7:50 (A. Dugan)
Fall BIOL0530 C08 16669 Th 7:00-7:50 (A. Dugan)
Fall BIOL0530 C09 16670 Th 8:00PM-8:50PM (A. Dugan)
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BIOL 0600. Genetic Screening in Model Organisms.

Using gene silencing (RNAi) in the nemotode C. elegans, students will identify genetic modifiers of proteins with roles in aging by reverse genetics. Analyzing the effect of knocking down genes on the level of aging-related proteins tagged with fluorophores (GFP, RFP, etc.). Students will use function-specific RNAi libraries (transcription factors, kinases, etc) established in our lab. Students will evaluate the effect of genetic modifiers on proteostasis and lifespan, also familiarize C. elegans work and appreciating the use of model organisms, the students will master microscopy, genetic crosses, gene silencing, and molecular and biochemical readout assays such as qPCR and immunoblotting. Expected: BIOL 0200 or equivalent.

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BIOL 0800. Principles of Physiology.

Introduction to the function of organ systems with an emphasis on human physiology, includes basic concepts in cell and organ system physiology as well as fundamentals of modern trends in physiological science, emphasizes the application of physical and chemical principles to organ function at both the cellular and systemic levels. Expected: BIOL 0200 or equivalent. S02 – You may take the lecture portion asynchronously If you have a class conflict during the lecture time. You Must identify the course in conflict for an override. The requirements for SO2 are in-person lab offered at various times during the week and taking the 3 exams on the same day they are scheduled. S03 – Virtual option for students who are not on campus. (see description)

Spr BIOL0800 S02 25933 Arranged (J. Stein)
Spr BIOL0800 S03 25934 Arranged (J. Stein)
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BIOL 0860. Diet and Chronic Disease.

This course addresses the relationship of food to the development and treatment of chronic diseases. Chronic diseases discussed are obesity, dyslipidemia/heart disease, diabetes mellitus, cancers and osteoporosis. Dietary recommendations for these diseases are critically assessed. Geared toward students interested in nutrition, medicine, and public health. Prerequisites: BIOL 0030, plus permission of the instructor. Enrollment limited to 20.

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BIOL 0920A. Controversies in Medicine.

Why and how do controversies in medicine emerge at specific moments in time? Why do scientists come to different conclusions based on the same data? Does it matter how we interpret controversies? This sophomore-level seminar critically analyzes contemporary controversies in medicine and public health. Using a case study approach, we will examine the social and political assumptions that inform important controversies. Questions related to the relationship between science, media, activism, and health inequality will be woven into the case studies. Enrollment limited to 20 sophomores. (For theme, not biology, credit in Health and Human Health and Biology only.)

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BIOL 0940A. Viral Epidemics.

This sophomore seminar will examine epidemics (outbreaks) of viral infections from a historical perspective. We will also cover current literature and up to the minute news accounts of infectious disease related outbreaks occurring around the globe. The major focus will be on virus related diseases but any microbial outbreak in the news will be explored. The seminar will cover basic aspects of microbial pathogenesis so students can gain an appreciation of microbial host interactions. Essential writing skills will also be developed. Enrollment limited to 20 sophomore students.

Fall BIOL0940A S01 10265 Th 4:00-6:30(04) (W. Atwood)
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BIOL 0940B. Sophomore Seminars in Biology: Life in a Shell.

This Sophomore seminar is an examination of broad themes in whole animal physiology with an emphasis on environmental adaptations. The foundation of the course will be the instructor’s recent book “Life in a Shell: A Physiologist’s View of Turtle.” A consideration of this iconic animal’s novel biological traits will lead into comparisons with our own biology and that of other animals. Topics: respiration, circulation, metabolic rate, buoyancy control, overwintering, migration, reproduction, and bone structure and function. Relevant original research papers will be used. Mandatory S/NC; enrollment of 20 students; override required. Expected: BIOL 0200 or equivalent placement credit.

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BIOL 0940C. Sophomore Seminar: Insect Biology.

Focuses on characteristics that make insects unique and why more insect species have been described than all other organisms combined; the opportunity to investigate diversity and adaptation; their abundance, small size, and short lifespans; their importance as agents of biocontrol pollination, agricultural pests, and disease vectors. Expected: BIOL 0200 or equivalent. Enrollment limited to 12 sophomores only. Students MUST register for lecture AND lab.

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BIOL 0940D. Rhode Island Flora: Understanding and Documenting Local Plant Diversity.

This Sophomore Seminar focuses on species level identification of plants in Rhode Island and will cover the dominant plant species in each of the state’s main habitats including coastal wetlands and uplands, freshwater wetlands, peatlands, upland forests, and disturbed areas. Students will learn to identify plants using online interactive keys as well as more technical dichotomous keys and will also cover basic ecological processes in each habitat including the interaction of soils, geology, and hydrology. Materials related to plant morphology, plant taxonomy, plant evolution, understanding phylogenetic trees, and botanical illustration. Instructor permission required.

Fall BIOL0940D S01 10290 F 1:00-5:00 (R. Kartzinel)
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BIOL 0940E. Precision Medicine or Privileged Medicine? Addressing Disparities in Biomedical Research.

This course examines the biomedical research behind precision medicine, disparities in the inclusiveness of this research, and implications of these disparities for the relevance of precision medicine innovations for people and places in Rhode Island. We will focus on these four questions: What new knowledge is making precision medicine possible? Who has been the focus of the biomedical research generating this knowledge, and why? How might inclusiveness of this research impact healthcare disparities in Rhode Island? What is needed to improve the design and outcomes of precision medicine research so that it provides benefits and mitigates harms for all?

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BIOL 0940G. Antibiotic Drug Discovery: Identifying Novel Soil Microbes to Combat Antibiotic Resistance.

This is a Course-based Undergraduate Research Experience (CURE) class that will provide students with the chance to propose, design and conduct their own research projects, working on topics and seeking answers to questions that are currently unknown to science. This course carries a COEX designation. Wintersession would prove to be a particularly useful timeframe for this course because students would be able to be fully immersed in their research project during this time compared to when they are juggling additional demands. Please NOTE: This course carries Biology concentration credit for the laboratory component, and also can be used for 1 semester of research towards the Biology ScB concentration.

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BIOL 0945. Toolbox for Scientific Research.

Why is scientific research important? What is the scientific method? What are hypotheses and theories? How do scientists identify research questions, design experiments, fund research, and communicate results? This sophomore seminar is designed for students who want to understand and engage in scientific research in biology. Through active learning seminars, group discussions, and meetings with scientists, students will gain a deeper understanding and an appreciation for the principles, practice, and culture of scientific research. The course will also help develop practical and transferable skills to succeed in research and give students an opportunity to connect with research groups at Brown.

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BIOL 0946. Research Design + Quantitative Methods for the Health Sciences.

This is a course offered for students in one of Brown University's Biology concentrations that provides the skills necessary to identify a clinical research question from a case scenario, design a research design to answer a research question, identify the appropriate quantitative methods for the design, and interpret the results. These skills translate to almost any research experience, including honors theses and future endeavors. Students will also learn how to publish in oral and written formats across the health sciences disciplines.

Fall BIOL0946 S01 10259 Arranged (K. Monteiro)
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BIOL 0960. Independent Study in Science Writing.

BIOL 0960 (fall/spring) is a half credit Independent Study in Science Writing course incorporating a nontechnical science journalism component into the Biology curriculum. Assignments may include investigative or analytical reviews, or feature articles on ethical or social impacts of new discoveries in the biological sciences. BIOL 0960 requires the submission of a formal project proposal completed collaboratively by the student and faculty mentor (see the Biology Undergraduate Education research page for details). BIOL 0960 is not for concentration credit in the biological sciences programs.

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BIOL 0985. Greenhouse Crops & Interiorscapes.

This is an applied-knowledge course designed to prepare students to be introduced to the management of greenhouse operations and basic interiorscaping design & practices. This course covers principles of greenhouse structures, plant health and growth, growing media, greenhouse crop selection and propagation, and management techniques. Upon completion of this course, proficient students will be equipped with the technical knowledge and skills needed to prepare in furthering their education. This course will focus on introducing students to the greenhouse space and teach them how the facility aids in producing plants for research and for enjoyment. The course will also explain general propagation techniques and the world of interiorscaping, and how to grow the plants used for this purpose, as well as exploring basic interiorscape design. The course does not carry Biology concentration credit.

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BIOL 1000. Quality Improvement Science and Application: From personal improvement to strengthening healthcare.

Have you ever set a goal, tried to accomplish it, failed, adjusted your routine, and tried again? If so, you have already engaged in quality improvement (QI)! QI is focused on how change is implemented in healthcare and in other settings (such as aerospace) with the goal of standardizing processes and reducing variation. QI is achieved through setting specific, measurable goals and making small, iterative changes; all while implementing and evaluating change. If you want to learn how to implement a change, sustain that change over time, and measure success, this course is for you. The project provides an opportunity to engage in QI in your life to implement and evaluate progress on a goal that is important to you (e.g., drinking more water, practicing better time management skills).

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BIOL 1040. Ultrastructure/Bioimaging.

This course examines microscopy and image analysis in the life sciences. Theoretical and practical aspects of microscopy will be discussed. Students will obtain hands-on experience with electron microscopy, light microscopy, fluorescence microscopy, and confocal microscopy. Students will learn to display images in 3D. Advanced undergraduates. Instructor permission required.

Spr BIOL1040 S01 20232 M 2:00-5:00 (G. Williams)
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BIOL 1050. Biology of the Eukaryotic Cell.

This course examines subcellular processes and structure/function roles of macromolecular complexes regulating major cellular activities in eukaryotic cells. Course content will cover cellular and molecular techniques in cell biology, functions of cellular compartments, and the organization and expression of genetic information in eukaryotes, comparing normal and pathological states. Lectures and readings will emphasize the experimental basis for knowledge in modern cell biology using original literature and current research in cell/molecular biology. You will learn to read and analyze published research as well as master current concepts and understanding of cellular structure and function. You will then apply this mastery to propose an original research project that would advance those understandings. For advanced undergraduates and beginning graduate students. Complementary to BIOL 1270 and 1540. Prerequisites: BIOL 0280 or 0470 or 0500, or instructor permission. Graduate students register for BIOL 2050.

Fall BIOL1050 S01 17977 TTh 1:00-2:20(06) (C. Toth)
Fall BIOL1050 C01 17978 Th 12:00-12:50 (C. Toth)
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BIOL 1070. Biotechnology and Global Health.

This course examines contemporary biotechnologies used to combat the predominant, worldwide problems in human health. Global health will be addressed from the scientific and engineering perspectives while integrating public health policy, health systems and economics, medical and research ethics, and technology regulation and management. This course is intended for graduate and advanced undergraduate students in biology, engineering, or related fields who have an interest in global health initiatives. Expected background: BIOL 0200 and BIOL 0800, or equivalents. Preference will be granted to graduate students in the Biotechnology and Biomedical Engineering programs. Only for related course credit in Biology. Enrollment limited to 20. Instructor permission required.

Fall BIOL1070 S01 10253 TTh 9:00-10:20(05) (J. Schell)
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BIOL 1090. Polymer Science for Biomaterials.

Basic principles of polymer science and its application in medicine. Topics include basic polymerization chemistry, kinetics of polymerization and depolymerization with emphasis on bioerodible polymers, characterization of polymers by physical methods, bulk and surface properties, behavior of polymers in solutions, crystallization, gelation, and liquid crystals. Hands-on experience with polymer characterization. Expected: CHEM 0350. Enrollment limited to 25.

Fall BIOL1090 S01 10283 Arranged (E. Mathiowitz)
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BIOL 1100. Cell Physiology and Biophysics.

Current topics in cell physiology, with an emphasis on membrane-mediated interactions between cells and their environment. Topics may include: ion channel structure, function and regulation; intracellular regulatory molecules; mechanisms of sensory transduction; membrane receptors and second messenger systems; vesicle secretion; and cytoskeletal regulation of cell function. Lectures, discussion, and student presentations of the current literature. Expected: BIOL 0800 or NEUR 0010. Instructor permission required. Enrollment limited to 30, and admission is based on seniority -- graduate students, seniors, then juniors. (Not for first and second-year undergraduates.) Students must request an override code through C@B.

Spr BIOL1100 S01 20246 M 3:00-5:30(13) (D. Horrigan)
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BIOL 1110. Topics in Signal Transduction.

Signal transduction is one of the most rapidly developing fields in biomedical sciences. Defects in signaling pathways can be responsible for diseases such as cancer, diabetes, cardiovascular disorders and psychoses. This course offers students an overview of the molecular pathways that allow cells to receive and process signals from their external environment, with an emphasis on the emerging state-of-the-art techniques used in their study. Expected background: BIOL 0200, 0280, 0470, or 0500.

Fall BIOL1110 S01 10258 W 3:00-5:30(10) (E. Oancea)
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BIOL 1120. Biomaterials.

A biomaterial is defined as a material suitable for use in medical implants that come in direct contact with patients' tissues. These include polymers, metals, and ceramics, and materials obtained from biological sources or through recombinant biotechnology. Goal: to provide comprehensive coverage of biomaterial science and technology. Emphasizes the transition from replacement to repair strategies. For advanced undergraduates and graduate students. Prerequisite: BIOL 0800 or instructor permission.

Spr BIOL1120 S01 20222 Arranged (Y. Dingle)
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BIOL 1140. Tissue Engineering.

Tissue engineering is an interdisciplinary field that incorporates progress in cellular and molecular biology, materials science, and engineering, to advance the goal of replacing or regenerating compromised tissue function. Using an integrative approach, we will examine tissue design and development, manipulation of the tissue microenvironment, and current strategies for functional reconstruction of injured tissues. Expected: CHEM 0330, plus BIOL 0500 or 0800. Enrollment limited to 20. Instructor permission required.

Fall BIOL1140 S01 17952 W 3:00-5:30(10) (D. Hoffman-Kim)
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BIOL 1150. Stem Cell Engineering.

Stem cell engineering focuses on using adult, embryonic, and induced pluripotent stem cells to repair damaged or diseased tissues. This course will examine the role of stem cells in development, tissue homeostasis, and wound healing, as well as how they can be used for tissue engineering and cell-based regenerative therapies. We will also discuss the ethical, legal, and regulatory issues that accompany current and emerging stem cell engineering endeavors. The course will use an inverted lecture and classroom discussion format to effectively deliver relevant information. Emphasis is placed on oral and written communication skills applied to assignments, tests, and individual projects. As an additional part of this course, students will receive hands-on training in how to culture cells and assess samples for stemness characteristics in a group laboratory setting. Course timing conflicts, particularly with the last hour of the Friday lab, can typically be accommodated through an overlap request.

Spr BIOL1150 S01 20249 Th 3:00-5:30 (E. Darling)
Spr BIOL1150 L01 25742 F 9:00-12:00 (E. Darling)
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BIOL 1155. Hormones and Behavior.

This class will explore the hormonal basis of animal behavior. We will assess this relationship at the molecular, cellular, physiological, and evolutionary levels, focusing on a wide range of species beyond humans. Our goal is to understand the diverse mechanisms by which hormones act throughout the animal body to mediate what individuals do in their natural environment. We will explore how selective forces shape these mechanisms to not only arrive at common behavior traits, but also unique and unusual traits that allow species to thrive in harsh or extreme environments.

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BIOL 1160. Principles of Exercise Physiology.

Application of the basic principles of physiology to the study of the response mechanisms of the human body during exercise. Topics include muscle and neural control, energy metabolism, cardiovascular and respiratory effects, endocrinology, principles of training, and special topics (e.g., diving, high altitude, and microgravity). Student presentations based on scientific articles are included. Expected: BIOL 0800 or written permission of the instructor.

Fall BIOL1160 S01 17788 MWF 12:00-12:50(15) (A. Smith)
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BIOL 1180. Comparative Animal Physiology.

Comparative approach to the function and regulation of animal systems with an emphasis on vertebrates. Topics include circulation, gas exchange, neuromuscular function, excretion, acid-base and ion regulation, and temperature regulation. Considers the unity and diversity of physiological processes in animals differing both in phylogeny and environmental adaptation. Original papers are discussed. Expected: BIOL 0800 or equivalent.

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BIOL 1190. Synaptic Transmission and Plasticity.

Synapses are the means by which the nervous system communicates. In this seminar-style course, we will explore the molecular and physiological underpinnings of synaptic transmission. We will then examine ways in which synapses can modulate their strength during development, learning, after addictive drugs, and other adaptive processes. Readings are ONLY from primary literature. Course recommended for juniors and seniors. Required: NEUR 1020. Enrollment limited to 20. Instructor's permission required, attendance at class on the first day is mandatory.

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BIOL 1200. Protein Biophysics and Structure.

Structural Biology is the science to determine 3-dimensional structures of biomacromolecules (i.e. proteins, RNA, and DNA). These structures enable biologists to understand and explore their function. Since proteins, RNA, and DNA are the primary molecules of life, structural biology enables us to understand and influence these molecular machineries which form the basis of all biological processes. Throughout the class, the students will see examples of biologically important proteins and protein complexes that will allow them to correlate structure and biological function. Prerequisite: BIOL 0280.

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BIOL 1210. Synthetic Biological Systems.

A multidisciplinary course that combines science and engineering providing a solid foundation in a cutting edge field of biological engineering. Synthetic biology is a mixture of biology, chemistry, engineering, genetic engineering and biophysics. It builds on recent work in systems biology which involves the modeling of biological systems, but goes further in that it involves the construction and standardization of biological parts, that fit together to form more complex systems. Expected: at least four courses beyond BIOL 0200, CHEM 0330, PHYS 0300, ENGN 0300, MATH 0900, or CSCI 0040.

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BIOL 1220. Synthetic Biological Systems in Theory and Practice.

A multidisciplinary laboratory, lecture, and discussion based course that combines several areas of science and engineering providing a foundation in the cutting edge field of synthetic biological engineering. The field of synthetic biology is centered around trying to make biology easier to engineer. It builds on recent work in systems biology which involves the modeling of biological systems, but goes further in that it involves the construction and standardization of biological parts that fit together making complex systems. This course will combine classes, guest lectures and discussion lab visits to give students the best possible tools for understanding and applying research in synthetic biology. Expected: at least two courses in any of the key disciplines (biology, chemistry, physics, math, engineering, computer science) beyond the introductory level, and permission of the instructor.

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BIOL 1222A. Current Topics in Functional Genomics.

A technological revolution in genomics has exponentially increased our ability to gather biological data. A host of new methods and types of analysis has arisen to accommodate this dramatic shift in data collection. The broad scope of inquiry has ushered in an era of “system-wide” approaches and brute-force strategies where rare signals can be detected and studied. In this seminar we will cover papers that embody this new approach. Students typically have taken an advanced undergraduate-level course in biology.

Fall BIOL1222A S01 18447 T 3:00-5:30 (E. Larschan)
Spr BIOL1222A S01 20234 W 3:00-5:30(10) (W. Fairbrother)
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BIOL 1250. Host-microbiome Interactions in Health and Disease.

Will focus on current understanding of how various microbiomes communicate and interact with the host and the factors that influence these interactions. We will discuss how the new technologies such as metagenomics and metabolomics have enhanced our understanding of host-microbiome interactions in health and disease. Students will have the opportunity to participate in discussions on how to apply recent discoveries to disease processes, health restoration and maintenance. The course will help students develop skills in critical thinking and in reading and evaluating original scientific literature. Expected: students with a background in basic microbiology (BIOL 0530 or its equivalent). 20 enrollment.

Spr BIOL1250 S01 20219 Th 2:00-4:30 (S. Vaishnava)
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BIOL 1255. Climate Change & Health: Infections and Inequalities.

This course examines the connections between people, animals, plants and their shared environment to highlight the influence of climate change on infectious disease and its disproportionate effect on impoverished communities. During the course, we will spotlight a several infectious diseases (HIV, Rabies, Ebola, Chagas), exploring their history, pathophysiology and geographic spread. We will discuss how climate change has influenced ecosystems, causing shifts in transmission and creating new challenges for treatment. We will use a biosocial approach to understanding how and why these changes disproportionately affect impoverished communities. You will learn using podcast episodes, news articles, research studies and documentaries. Several guest speakers will supplement course materials and guide activities. This course offers the opportunity to learn about climate change & health using a One Health and biosocial approach.

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BIOL 1260. Physiological Pharmacology.

Covers the physiology of human disease (e.g., Heart failure and arrhythmia; cancer signaling pathways with a focus on breast cancer; neurological disorders such as schizophrenia and Parkinson's disease) and discusses the pharmacology of the drugs used to treat disease. A group of the most commonly prescribed drugs is discussed in terms of their fundamental modes of action and clinical importance. Expected: BIOL 0800.

Fall BIOL1260 S01 10266 TTh 10:30-11:50(13) (J. Marshall)
Fall BIOL1260 S02 10267 Arranged (J. Marshall)
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BIOL 1270. Advanced Biochemistry.

An advanced course in biochemistry, biochemical methods, and reading of the primary literature, featuring systematic coverage of the biochemistry of the central dogma, including DNA (replication, repair, recombination), RNA (regulation and mechanism of transcription, processing, turnover), and proteins structure, synthesis, modification, degradation, mechanisms of action, function). Expected: BIOL 0280, CHEM 0350, 0360. Graduate students register for BIOL 2270.

Fall BIOL1270 S01 10270 TTh 2:30-3:50(12) (A. Salomon)
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BIOL 1290. Cancer Biology.

Provides a conceptual understanding of molecular events underlying development of human cancer. Focused on genetic changes leading to malignant transformation of cells. Covers cell cycle control, DNA damage, mutagenesis, cancer predisposition syndromes, oncogenic viruses, tumor immunology, metastasis, cancer chemotherapy and drug resistance. Lecture plus discussion of primary literature. Prerequisites: BIOL 0280 OR BIOL 0470 OR BIOL 0500.

Fall BIOL1290 S01 10306 MW 3:00-4:20(10) (A. Zhitkovich)
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BIOL 1295. Fundamentals of Cancer Immunotherapy.

Fundamentals of Cancer Immunotherapy focus on how are understanding of the relationship of cancer with the host immune system has allowed the development of a new generation of therapies. The course will be delivered by lecture/seminar and group discussions. The course covers contemporary knowledge of tumor-immune cell interactions, and the principles of immunotherapeutic approaches currently being applied in the clinic and in development. The course is designed so that students will view cancer immunotherapy through a range of different lenses; from intricate molecular details to cellular ecosystems and organismal effects. Lecture materials will provide detailed descriptions of the basic concepts involved and original research articles will be used to help develop critical thinking in the cancer immunotherapy field.

Recommended Prerequisites: At least two of the following or their equivalents: BIOL 0280, BIOL 0500, BIOL 0470, BIOL 0530, BIOL 1290

Spr BIOL1295 S01 26130 MW 3:00-4:20(10) (S. Lawler)
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BIOL 1300. Biomolecular Interactions: Health, Disease and Drug Design.

Interactions between the molecules of life-proteins, RNA, DNA, membrane components-underlie all functions necessary for life. This course focuses on how nature controls these interactions, how these interactions can go awry in disease, and how we can learn the rules of these interactions to design drugs to treat disease. Students will review the physical basis of molecular interactions, learn classic and state-of-the-art high-resolution and high-throughput tools used to measure interaction, and survey the experimental and computational strategies to harness these interactions using a case study in rational drug design. Prerequisite: Introductory Biochemistry (BIOL 0280). Enrollment limited to 20; instructor permission.

Fall BIOL1300 S01 10272 M 3:00-5:30(03) (N. Fawzi)
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BIOL 1310. Developmental Biology.

Covers the molecular and cellular events of development from fertilized egg to adult. Genetic basis of body form, cell fate specification and differentiation, processes controlling morphogenesis, growth, stem cells and regeneration will be examined. Differential gene regulation, intercellular signaling and their evolutionary conservation will be central to discussion of mechanisms governing developmental processes. Additional topics: developmental plasticity, impact of epigenetic and environmental factors, and basis of disease gleaned from developmental biology research. Live embryos will complement and reinforce concepts covered in class. Enrollment limited to 36. Expected: BIOL 0200 (or equivalent), and one course in genetics, cell biology or embryology.

Fall BIOL1310 S01 10274 TTh 9:00-10:20(05) (K. Wharton)
Fall BIOL1310 L01 16686 W 1:00-5:00 (K. Wharton)
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BIOL 1330. Biology of Reproduction.

This course is an advanced, seminar-based course. Primary literature is emphasized to complement the format of extensive student seminar presentations. It is essential that students have a strong background in biology in order to gain the most from this course. The emphasis of the course is student seminar presentation and extensive discussion on the material. This is often the first opportunity for students to present/discuss science in a seminar format. Expected background: a course in Cell Biology (e.g. BIOL 0500 or 1050), and two additional Biology courses above the introductory (BIOL 0200) level. Enrollment limited to 20.

Spr BIOL1330 S01 20236 M 3:00-5:30(13) (G. Wessel)
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BIOL 1410. Evolutionary Genetics.

This course will focus on selected topics in molecular population genetics, molecular evolution, and comparative genomics. Classic and current primary literature at the interface of evolution and genetics will be discussed in a seminar format. The laboratory involves wet-lab exercises (allozymes, PCR- RFLP, sequencing), plus computer labs using DNA analysis packages. Students will prepare a final grant proposal on specific research interests. Expected: BIOL 0470 or 0480. Students MUST register for the lecture section and the lab. Enrollment limited to 20.

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BIOL 1420. Experimental Design in Ecology.

An overview and discussion of the basic principles used to design lab and field experiments in ecology and environmental science. Topics include: replication and statistical power, appropriate use of factorial designs, nonparametric methods, post hoc texts, natural versus manipulative experiments, experimental artifacts and impact study design. Discussions based on primary literature and a new text. Expected: BIOL 0420.

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BIOL 1425. Phylogenetic Biology.

This course is the study of the evolutionary relationships between organisms, and the use of evolutionary relationships to understand other aspects of organism biology. This course will provide a detailed picture of the statistical, mathematical, and computational tools for building phylogenies and using them to study evolution. Enrollment is by instructor permission. Students will present scientific papers in class and complete a final project consisting of their own phylogenetic analysis. Expected Background: Evolutionary Biology and quantitative methods (such as statistics, computation, or math). Open to juniors, seniors, and graduate students. Enrollment limited to 16.

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BIOL 1430. Foundations of Population Genetics.

Population genetics considers the genetic basis of evolution: temporal changes in the genetic composition of populations in response to processes such as mutation, natural selection and random sampling effects. Starting from first principles, this course will develop a theoretical understanding of these dynamics. We will also explore the application of these tools to genomic-scale data in order to quantify the influence of various evolutionary processes at work in natural populations. Assessments will be based on problem sets, two midterm exams and one final exam. Prerequisites: MATH 0100 and one of BIOL 0470 or 0480, or permission.

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BIOL 1435. Computational Methods for Studying Demographic History with Molecular Data.

This course broadly covers the field of population genetics and genomics, and focuses on how inferences about demographic history can be made from genetic variation observed across populations today. The main question we will endeavor to answer in class is “How can we infer demographic history in a population using next-generation sequencing data?” Students will also learn how to apply computational tools/methods to infer demographic history using both simulated and real DNA sequencing data.

Spr BIOL1435 S01 20256 Arranged (E. Huerta-Sanchez)
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BIOL 1440. Coral Reef Ecology.

An examination of current topics in the biology of corals and the ecology and conservation of coral reefs in the Anthropocene. The seminar course sessions include an introductory lecture on the topic at hand coupled with discussion of assigned papers in the recent scientific literature. The course follows ecological principles to examine key species interactions, biodiversity patterns and consequences, trophic dynamics, pathways of resilience and regime shifts on coral reefs. This foundation builds the knowledge needed for advanced discussions of the effect of global climate change on coral reefs during the latter part of the course. Students select a contemporary topic to investigate and prepare a critical evaluation of research on that topic as a final term paper.

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BIOL 1445. Medicine in Austere Settings.

This course examines the practice of medicine in austere settings and will include content related to tropical medicine/neglected tropical diseases, humanitarian relief, disaster management and wilderness medicine. Students will explore the history of these fields and the challenges that medical professionals face in these environments. The course will focus on the multitude of ethical dilemmas when providing care in austere settings. Students should expect to think critically about challenging questions and learn various skills useful to the practice of medicine in austere settings, including basic epidemiology, public health coordination, disaster management and wilderness medicine techniques. Each week will feature a different scenario to tackle. Students will learn using podcast episodes, news articles, research studies, and documentaries. This course is well-suited for students who are interested in public health, international health policy or aim to pursue a career as a medical professional.

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BIOL 1450. Community Ecology.

This course will explore foundational concepts in community ecology, and will draw on examples and case studies from marine and terrestrial ecosystems, including species-rich tropical rain forests and coral reefs, the marine intertidal and benthic environments, and species-poor forests and grasslands of the temperate zone. Overarching themes will emphasize theoretical frameworks to understand the evolutionary origins and maintenance of this biological diversity. This will be accomplished using traditional lectures, weekly student-led discussions, readings of the primary literature, and class activities. Expected background: BIOL 200 or equivalent placement; and BIOL 0420; OR instructor permission.

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BIOL 1455. Planetary Health: Global Environmental Change and Emerging Infectious Disease.

Will a warmer world be a sicker world? What is it about the New England landscape that supports the proliferation of Lyme Disease? How are local wildlife trade and global species invasions contributors to emerging diseases like the 2003 outbreak of monkeypox virus in the USA? We will explore these and related questions in Planetary Health. Planetary health is a timely new field focused on understanding the human health implications of human-caused disruptions to Earth's natural systems. The facet of ‘health’ that we focus on in this course is infectious disease. Students will learn how, when, where and why infectious diseases emerge in association with anthropogenic environmental impacts, specifically climate change, land-use change, and increased human interaction with animals. This course satisfies the Health and Human Biology senior capstone requirement for students studying in the planetary health theme.

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BIOL 1465. Human Population Genomics.

An introduction to human genomics and the evolutionary forces that shape observed genetic variation across humans today. Topics will include the relationship among humans and other primates, human population genetics and genomics, and examples of the concomitant evolution of both cultural traits and domesticated organisms. Assignments include a class presentation and reviewing papers on a selected topic. Expected background: BIOL 0470 or 0480, and BIOL 0495, PHP 2500, or equivalent. Enrollment limited to 25. Instructor permission required.

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BIOL 1470. Conservation Biology.

Conservation Biology is the scientific study of the phenomena that affect the maintenance, loss, and restoration of biological diversity. Topics covered include: 1) the impacts of global warming, species invasions, and habitat destruction on biodiversity, 2) strategies developed to combat these threats, and 3) a consideration of key economic and ethical tradeoffs. Special attention will be paid to current debate and controversy within this rapidly emerging field of study.

Fall BIOL1470 S01 10294 TTh 9:00-10:20(05) (D. Sax)
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BIOL 1480. Terrestrial Biogeochemistry and the Functioning of Ecosystems.

Three fundamental multidisciplinary questions will be addressed: How do ecosystems work? What limits the growth of life on Earth? How are humans altering the framework in which all life exists? Earth is basically a closed chemical system, and the reactions that support life are fueled by sunlight. But added to this chemistry and physics is the tremendous influence of life. Life created an oxygen atmosphere; the evolution of biological nitrogen fixation exponentially increased how many organisms could exist, and the soils that support human food production developed only by biologically-mediated processes. Throughout Earth's 4.5 billion-year history changes in Earth's basic biogeochemical processes have been fairly slow. Under our inattentive stewardship, we have almost instantaneously altered all of the major element cycles. We will focus heavily on what these changes mean for life on Earth. Instructor permission required.

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BIOL 1485. Climate Change Health and Ecology.

Explore the linkages between climate change and health. Students will come to appreciate the topic through the foundations of the primary disciplines relevant to the field including global health, environmental change, disease ecology, and others. Climate-health linkages will be learned through weekly case studies addressed collectively through student-centered lectures, discussion of the primary literature, groups activities and guest lectures from campus faculty on topics ranging from climate migration to infectious disease range shifts. Expected background: BIOL 0475, or BIOL 1470, or PHP 1070, or PHP 1920, or equivalent experience with instructor's permission. Enrollment limited to 12 juniors and seniors.

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BIOL 1495. 500 Million Years of Land Plants.

Explores the evolution of terrestrial plants and the ecosystems they structure. Introduces the fossil record of plants and basic patterns of plant diversification on land. Highlights major trends in the evolution of plant morphology, anatomy, and ecology. Lectures survey the diversity and community structure of different geological time periods. Weekly discussion sections, field trips, and assignments examine major evolutionary trends, particularly with regard to climatic changes over time. Expected: BIOL 0400, BIOL 0430, (or equivalent placement). Enrollment limited to 15 students; instructor permission; register for section and conference.

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BIOL 1500. Plant Physiological Ecology.

An in-depth look at plant ecological strategy, focusing on the anatomical and physiological adaptations of plants to particular environments. Additional topics include plant-animal interactions, historical biogeography, and community assembly processes. A comparative, phylogenetic approach is emphasized. Lectures present a broad overview of topics, and discussions focus on current outstanding problems. Lab exercises provide hands-on experience in designing experiments, measuring plant performance, and scientific writing. Required laboratory hours to be arranged by the instructor. Expected: BIOL 0430 or BIOL 0440. Enrollment limited to 15.

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BIOL 1505. Environmental Physiology.

This course seeks to explore the physiological mechanism by which animals are adapted to live in our planet’s diverse habitats. We study this topic by considering the physical and chemical properties of the environment, and how these properties shape the organismal functioning and performance. No animal is off limits to our exploration, as we will look at both vertebrates and invertebrates alike. Overarching themes will emphasize the power of natural selection as an evolutionary force that writes the “rules” of life, particularly in terms of survival.

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BIOL 1515. Conservation in the Genomics Age.

The course will introduce students to the rapidly developing field of molecular ecology, emphasizing its importance for conservation biology. Students will explore key principles in evolutionary ecology based on readings, lectures, and discussions. Participants will also gain practical experience with ecological, genomic, and computational methods in the lab. This course is intended for advanced undergraduate and graduate students. Suggested prerequisites include Principles of Ecology (0420); Evolutionary Biology (0480) or Genetics (0470); the Lab Techniques Workshop for Biology Students provided by MDL; or similar with permission. Students will obtain permission from the professor to enroll.

Fall BIOL1515 S01 10291 MWF 9:00-9:50(09) (T. Kartzinel)
Fall BIOL1515 L01 16687 W 1:00-4:00 (T. Kartzinel)
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BIOL 1520. Innate Immunity.

Innate immunity is the initial response to microbes that prevents infection of the host. It acts within minutes to hours, allowing the development of the adaptive response in vertebrates. It is the sole mechanism of defense in invertebrates such as insects. The components and mechanisms dictating this response are explored. Prerequisite: BIOL 0530. Enrollment limited to 30. Graduate students must obtain instructor permission.

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BIOL 1530. Emergency Medical Systems: An Anatomy of Critical Performance.

Students taking BIOL 1530 will explore Emergency Medicine and the many subjects that make up the practice of providing care to patients at the most critical and dire moments of their lives. We will read, discuss, and write about Trauma, Medical Malpractice, Death and Dying, Refugee and Disaster Medicine, Interpersonal Violence, and Crisis focused Medical Ethics, among others, all viewed through the lens of Emergency Medicine. You will shadow in the Emergency Department of a Trauma Center and debrief with your TA’s in weekly meetings, where the class topics will be discussed in open forums. This class, formerly PHP1520, has created a transformative experience for more than 30 years and will continue to foster new perspectives and ideas for every student who participates.

Spr BIOL1530 S01 20259 W 3:00-5:30(10) (B. Becker)
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BIOL 1540. Molecular Genetics.

Even in this era when whole genome DNA sequencing has become routine, there are still thousands of eukaryotic genes with unknown functions. Genetic screens for mutations that alter pathways of interest remain the premier approach to understanding gene function in the context of the organism. In Molecular Genetics students will learn the key concepts involved in designing and interpreting genetic screens using the powerful tools available in model animal, plant, and fungal organisms. Students will also learn how to understand and analyze results presented in the primary scientific literature. Furthermore, students will gain an appreciation of how the field of genetics has changed through discoveries and technological advances made over the past 50 years. Graduate students should register for BIOL 2540.

Spr BIOL1540 S01 20237 TTh 2:30-3:50(11) (Y. Huang)
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BIOL 1545. Human Genetics and Genomics.

This course will exemplify the power of genetically informed approaches to understanding human biology. It is intended for advanced undergraduate students and graduate students; prerequisites include BIOL0470 or equivalent. The course is based in lectures, reading material (textbook and primary literature), and in-class discussions. Course topics include: medical genetics and genomics; methods to study human genotypes and related phenotypes; industry-related topics; and ethical and societal implications of genome science. It will benefit students with career interests in basic science, medicine, biotechnology, or science policy. Enrollment is limited to 20 students; selection will be based on seniority, prerequisites, and registration order.

Spr BIOL1545 S01 20239 W 3:00-5:30(10) (E. Morrow)
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BIOL 1550. Parasitism: Biology and Disease.

Protozoan parasites influence the health of human populations in less developed countries, leading to severe human suffering and loss of economic development. Understanding the fundamental biology of these pathogens and how they are transmitted is essential for developing treatments and mitigation strategies to improve human health. Focuses on biochemical, genetic, cellular, and immunological aspects of parasite and host responses. Expected: BIOL 0470 or BIOL 0530.

This course was formerly "Biology of Emerging Microbial Diseases"

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BIOL 1555. Methods in Informatics and Data Science for Health.

The goal of this course is for students to develop a solution that uses data science and informatics approaches to address a biomedical or health challenge. This course will teach informatics and data science skills needed for public health and biomedicine research. Emphasis will be given to algorithms used within the context of biomedical research and health care, including those used in biomolecular sequence analysis, electronic health records, clinical decision support, and public health surveillance. This course has been developed as a Course-based Undergraduate Research Experience (CURE), where students will gain experience with the scientific method, its application, and presentation.

Spr BIOL1555 S01 20221 M 3:00-5:30(13) (E. Chen)
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BIOL 1560. Virology.

Emphasizes the understanding of molecular mechanisms of viral pathogenesis. Begins with a general introduction to the field of virology and then focuses on the molecular biology of specific viruses that are associated with human disease. Lectures based on current literature. Prerequisite: BIOL 0280, 0470, or 0530, or instructor permission.

Fall BIOL1560 S01 10248 MWF 9:00-9:50(09) (A. Jamieson)
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BIOL 1565. Survey of Biomedical Informatics.

Survey course provides overview of field of biomedical informatics. Topics include computer science, healthcare, biology, social science. This course is designed to be complementary to BIOL 1555. Emphasis given to understanding the organization of biomedical information, effective management of information using computer technology, impact of such technology on biomedical research, education, patient care. Major aim explores the process of developing and applying computational and information science techniques for assessing current information practices, determining information needs of health care providers and patients, developing interventions or supporting clinical practice using informatics, and evaluating the impact of informatics solutions from a biomedical perspective.

Fall BIOL1565 S01 10250 M 3:00-5:30(03) (N. Sarkar)
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BIOL 1575. Evaluation of Health Information Systems.

This course covers the field of evaluation of health information systems (HIS) in a range of roles and environments, in the US and worldwide. It includes topics in health information system (HIS) design and deployment, healthcare workflow, quantitative and qualitative evaluation methods and socio-technical environment for HIS. Emphasis is given to understanding the range of evaluation questions that can be asked, identifying the key stakeholders, understanding available evaluation techniques, and designing rigorous but achievable studies. Examples will include Open Source systems, medical Apps, and economic evaluation, the role of evaluation frameworks and theories, and notable HIS successes and failures. Recommended: past or concurrent enrollment BIOL 1565 or a public health course covering clinical research.

Fall BIOL1575 S01 10251 TTh 1:00-2:20(06) (H. Fraser)
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BIOL 1595. Artificial Intelligence in Biomedicine.

This course will teach the fundamental theory and methods of artificial intelligence (AI) alongside their application to the biomedical domain. It will give a representative overview of traditional methods as well as modern developments in the areas of (deep) machine learning, natural language processing and information retrieval. The course is designed to be accessible to non-computer science audiences and will not require extensive prior programming experience. The course will be accompanied by practical assignments applying the discussed techniques in a biomedical context. Understanding of formal theoretical knowledge will be assessed in a final exam. The course is designed for students concentrating in domains such as Computational Biology and Applied Mathematics-Biology; or Neuroscience concentrators who have completed a course in introductory statistics (e.g., BIOL 0495).

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BIOL 1600. Development of Vaccines to Infectious Diseases.

Provides background steps involved in vaccine development, from conceptualization to production to deployment. Considers infectious diseases and associated vaccines in context of community health. Appropriate for students wanting to gain an understanding of vaccine science. Provides a foundation for advanced courses in immunology and infectious disease, biomedical research, or medical/graduate studies. Activities include a weekly section meeting for discussion of relevant primary literature, and a final project of the student’s choice in the form of an in–class presentation, a research paper or an approved alternative format. Expected: BIOL 0200 or equivalent placement; BIOL 0530, and at least one additional biology course.

Spr BIOL1600 S01 20220 Arranged (S. Vaishnava)
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BIOL 1610. Experimental Neurobiology.

Intensive laboratory experience in neuroscience appropriate for students with basic background in Neurobiology. Learn and employ the classical neurophysiological techniques of extracellular recording, intracellular recording and receptive field mapping using a variety of animal species. Experiments will include recording of sensory signals in the cockroach leg; frog sciatic nerve and sciatic nerve/muscle preparation; intracellular recording of neurons in Aplysia; receptive field mapping in frog skin; and visual field mapping in the frog tectum. Instruction on and practice of effective science writing is another component to this course. Labs are supplemented by informal lectures. Enrollment limited to 18. Please request override through C@B. Overrides will not be given until after the first course meeting.

Spr BIOL1610 S01 26123 W 1:00-6:00 'To Be Arranged'
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BIOL 1630. Big Data Neuroscience Lab.

Recent technological developments have transformed neuroscience research, enabling us to generate comprehensive 'big data' sets that are often shared freely amongst the neuroscience community. This lab course will explore strategies to effectively use such open-sourced neuroscience data sets. Students will identify fundamental open questions in brain science and develop strategies to mine open-source sequencing, imaging and connectivity data to address their research questions.

Fall BIOL1630 S01 17965 Arranged (A. Fleischmann)
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BIOL 1650. Structure of the Nervous System.

Combined lecture and laboratory course on the anatomy of the central nervous system. Lectures survey the circuitry of the major neural systems for sensation, movement, cognition, and emotion. Laboratory exercises (Mon. 10:30-12:30) include brain dissections, microscopy of neural tissue, and discussion of clinical cases. Prerequisites: NEUR 0010, NEUR 1020, and NEUR 1030. Please request an override through C@B. Please keep in mind that decisions on overrides may not be made until the first meeting of the course.

Fall BIOL1650 S01 10282 TTh 2:30-3:50(12) (D. Berson)
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BIOL 1800. Animal Locomotion.

How and why do animals run, jump, swim and fly? Physiology, anatomy, ecology, and evolutionary history all influence, and are influenced by, the way animals move around. We will integrate analyses from many levels of biological organization - from molecular motors, through bone-muscle systems, to biogeography - with methods and approaches from mechanics, fluid dynamics, and robotics. Expected: BIOL 0800 and PHYS 0030. Instructor permission required.

Fall BIOL1800 S01 10293 Arranged (S. Swartz)
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BIOL 1810. 21st Century Applications in Cell and Molecular Biology.

Twenty-first century applications in cell and molecular biology focuses on the structure and function of macromolecules and cells and how they are altered in disease and therapy. This course will explore physical principles underlying cell function, along with biophysical approaches for solving problems of cell and molecular biology. Cutting-edge molecular and cellular-based therapeutics will be discussed throughout this course; this includes viral gene delivery constructs, novel platforms for tissue engineering, CRISPR genome editing, and immune checkpoint therapy. This course is particularly suitable for undergraduate students interested in basic medical research, graduate school, or research-based careers in biotechnology or pharmaceutical industry.

Spr BIOL1810 S01 20242 MWF 10:00-10:50(03) (M. Dawson)
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BIOL 1820. Environmental Health and Disease.

Humans live, work, and play in complex chemical environments. BIOL1820 examines how environmental exposures impact health and contribute to disease. We will discuss contamination in the context of colonialism and capitalism as well as critically assess the ways society shapes science as a discipline. The course covers basic concepts in toxicology, physiology, and molecular biology and is divided into 6 units. The first unit, Science, Society, and Scientific Funding, will introduce you to the main themes of the course. The remainder of the course will be divided into the following units: radiation, lead, per- and polyfluoroalkyl substances (PFAS), endocrine disruptors, and emerging environmental concerns. For each unit, students will learn how contamination affects different communities and examine the biological systems impacted by contaminant exposure. BIOL1820 is designed for third and forth year undergraduates, and is open to others with permission.

Spr BIOL1820 S01 20269 Arranged (J. Plavicki)
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BIOL 1850. Environmental and Genetic Toxicology.

Human disease is produced by complex interactions between inherited genetic predisposition and environmental exposures. These interactions will be explored at the molecular, cellular, and systemic levels. Prototype diseases will include hereditary disorders of hemoglobin, hypercholesterolemia, birth defects, and cancer. Expected: Cell Biology.

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BIOL 1865. Toxicology.

Toxicology is the science that describes the adverse biological effects of exogenous chemical and physical stressors, including environmental, industrial, and agricultural chemicals and pharmaceuticals. This course will introduce the principal biological processes that determine an organism’s response to a toxicant, including absorption, distribution through a biological system, metabolism, elimination, and effects at the site(s) of action. We will discuss modern challenges in toxicology, such as assessing toxicity of mixtures and testing some of the thousands of untested chemicals in commerce. The material will be presented in lecture and student-led discussions, with readings from the toxicology literature.

Spr BIOL1865 S01 20270 TTh 1:00-2:20(08) (D. Spade)
Spr BIOL1865 S02 25752 Arranged (D. Spade)
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BIOL 1870. Techniques and Clinical Applications in Pathobiology.

A methodology course featuring laboratory and lecture instruction in established and leading-edge technologies. Examples: flow cytometry (multi-parameter analysis, cell sorting); molecular biology (PCR, real time PCR, in situ hybridization, microarrays, DNA sequencing, bioinformatics); digital imaging (image acquisition, processing and analysis); confocal microscopy ; histology and immunohistochemistry(confocal, immuno-histochemistry).

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BIOL 1880. Comparative Biology of the Vertebrates.

The biology, structure, and evolutionary history of the vertebrates considered phylogenetically, emphasizing evolution of the major body systems. Stresses an evolutionary approach to the correlation of structure and function with environment and mode of life. Labs include dissection of several different vertebrates and comparative osteological material. Emphasis of course is on critical thinking rather than memorization of material. Recommended: BIOL 0320 or 0800. First year students must obtain instructor permission to register. Enrollment limited to 32. Students MUST register for the lecture section and the lab.

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BIOL 1885. Human Anatomy and Biomechanics.

Human Anatomy and Biomechanics examines the structure of the human body from the perspectives of biomechanics, evolution, and development, focusing on the musculoskeletal system, sensory systems, and the complex, multifunctional organ of the human skin. The course considers biological form and function at multiple levels of organization and in diverse contexts, and offers students opportunities to synthesize, question, and write about ideas presented in class. The course includes a weekly, 2-hr laboratory section in which students will use kinesthetic learning to develop deep knowledge of anatomico-medical terminology, study osteology and develop powers of observation working with human and non-human animal bones, dissect a preserved rabbit specimen to learn the soft-tissue anatomy of a mammal and visit the human anatomy dissection lab at the Alpert Medical School.

Spr BIOL1885 S01 20257 TTh 1:00-2:20(08) (S. Swartz)
Spr BIOL1885 L01 25754 W 3:00-5:00 (S. Swartz)
Spr BIOL1885 L02 25755 Th 3:00-5:00 (S. Swartz)
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BIOL 1890. Human Histology.

This course will provide an in-depth treatment of the “stuff we are made of” and the wonderful logic of its organization. This course focuses fi rst on the biology of the four basic tissues (epithelium, connective tissue, muscle and nerve) and second, how they contribute to the functional anatomy of all organs and systems. For Pfizer students only.

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BIOL 1920C. Social Contexts of Disease.

What shapes our understandings of disease, and what makes a disease real? How might we explain the demise of formerly prevalent diseases and the arrival of others? How do politics, technologies, and institutions affect conceptions of disease and structure their treatment? Will examine the impact of social context on patients' experiences of disease, including clinical, scientific, and public health approaches. Will consider disease in relation to social relationships, power of the state to regulate disease, and cultural care of the body. Enrollment limited to 20 students; instructor permission required; serves as Capstone in Health and Human Biology. Not for concentration credit.

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BIOL 1941A. Plants in a Changing Planet.

Plants are the foundation of Earth's ecosystems and essential to human survival and civilization. This seminar will examine the physiological, ecological, and evolutionary responses of plants to rapid environmental change, and the consequences for agriculture and the structure and function of natural systems. Expected background: at least one of the following courses - BIOL 0420, 0430, 0440, 0480, or ENVS 0490.

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BIOL 1945. Outbreaks and Infections: Harnessing History and Preventing Future Epidemics.

This senior capstone course will investigate epidemic diseases that have plagued mankind in the past and explore the factors that contribute to the continued spread of diseases today. This course will emphasize the biology of both infectious and noninfectious diseases by exploring mechanisms of spread, pathogenesis, and prevention. Attention will also be given to environmental, economic, geographical, and social contributors to disease. Interactive class discussions, student presentations, analysis of primary literature, and multimedia homework will develop student skills culminating in an independent research project that dissects the life history of a disease and provides a forward-thinking strategy to combat it.

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BIOL 1950. Directed Research/Independent Study.

Directed research/independent study in biological sciences: basic science, social studies of biomedical science, and clinically-oriented projects, mentored by individual faculty members in the Division of Biology and Medicine. Sites include campus and hospital based facilities. Projects can serve as the basis for Honors theses, or to fulfill research requirements in a Bio-Med concentration program. Students planning to use 1950/1960 to fulfill a concentration requirement must receive approval from the concentration advisor. No more than two (2) semesters of BIOL 1950/1960 may be used toward a concentration program in the biological sciences. Faculty from outside the Division may supervise projects for bio-med program concentrators, but should do so using their Department's own Independent Study course number.

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BIOL 1960. Directed Research/Independent Study.

Directed research/independent study in biological sciences: basic science, social studies of biomedical science, and clinically-oriented projects, mentored by individual faculty members in the Division of Biology and Medicine. Sites include campus and hospital based facilities. Projects can serve as the basis for Honors theses, or to fulfill research requirements in a Bio-Med concentration program. Students planning to use 1950/1960 to fulfill a concentration requirement must receive approval from the concentration advisor. No more than two (2) semesters of BIOL 1950/1960 may be used toward a concentration program in the biological sciences. Faculty from outside the Division may supervise projects for bio-med program concentrators, but should do so using their Department's own Independent Study course number.

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BIOL 1970A. Stem Cell Biology.

Senior seminar course will provide an interactive forum by which up to twenty seniors (and qualified juniors with permission) will explore the biology of stem cells from their humble beginnings in the embryo to their potential use in regenerative medicine. The potency and regulation of embryonic and adult stem cell populations derived from diverse organisms will be contrasted with laboratory-derived human stem-like cells for biomedical applications. Critical reading of classical and modern literature in the field of stem cell biology will form the basis of student-led presentations, papers and ethical forums. Expected: biochemistry, genetics and/or cell biology. Instructor permission.

Fall BIOL1970A S01 10276 M 2:00-4:30 (R. Freiman)
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BIOL 1980. HIV/AIDS in Diverse Settings: Focus on Israel.

Participants in this winter session course will explore HIV/AIDS within the context of Israel’s diverse society, unique demographics and universal healthcare. While in Israel, students will visit clinics, hospitals, and universities, engage with health care providers, experts in the field and populations with HIV. By the end of the course students will gain research skills and an understanding of this pandemic, its management and challenges in Israel, and how this important disease is modulated through risk factors, healthcare systems, medical innovations, and socio-economic factors. There is no need for prior experience in any associated discipline or any knowledge of Hebrew.
Course schedule: January 2-6, 2023 - daily seminars at Brown (including student and guest lectures); January 7-16 - tour in Israel; January 17 - rest day; January 18-24 - daily seminars at Brown.

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BIOL XLIST. Courses of Interest to Biology Concentrators.

Biology

The Biology concentration invites students to study, in depth and in breadth, the science of life and living matter. Whether pursuing the Bachelor of Arts (A.B.) or Science (Sc.B.) in biology, students can expect to learn broadly in the discipline through a selection of courses in three areas: cell and molecular biology, structure and function, and organismal biology. In addition, students pursuing the Sc.B. complete a thematic track through which they gain an in-depth understanding of a particular subfield such as, Immunopathology, Ecology and Evolutionary Biology, Physiology/Biotechnology, Cell and Molecular Biology, Physical Sciences. The concentration also emphasizes practical skills and experimental design. Concentrators are required to take at least 3 courses with a laboratory or fieldwork component. Within all of these requirements, students have a high degree of flexibility and choice. Broad research opportunities are also available across several departments within the basic sciences as well.

Standard program for the A.B. Biology

The concentration program for the A.B. in Biology consists of four prerequisite courses in math, chemistry, and a statistics course as well as ten courses in biological sciences, including  at least one course in each of the following three areas: Area 1: Cell/Molecular Biology, Area 2: Structure/Function, and Area 3: Organismal Biology.

The Biology A.B. Concentration Worksheet may be a useful tool for course planning.

Prerequisites: 1
Equilibrium, Rate, and Structure
Organic Chemistry I
Single Variable Calculus, Part I (or placement. MATH 0050/MATH 0060 may be substituted for MATH 0090.)
One of the following:
Single Variable Calculus, Part II (or placement)
Single Variable Calculus, Part II (Accelerated) (or equivalent placement)
Or a statistics course, to be approved by the concentration advisor.
Ten Core Courses: 2,3,4
BIOL 0200The Foundation of Living Systems (Required course; AP credit or similar IB or A-levels accepted, placement test available.)1
Area 1 (Cell/Molecular Biology)1
Biochemistry
Genetics
Cell and Molecular Biology
Introductory Microbiology
Principles of Immunology
Biology of the Eukaryotic Cell
Developmental Biology
Conservation in the Genomics Age
21st Century Applications in Cell and Molecular Biology
Toxicology
Principles of Neurobiology
Area 2 (Structure/Function)1
Biological Design: Structural Architecture of Organisms
Invertebrate Zoology
Inquiry in Plant Biology: Analysis of Plant Growth, Reproduction and Adaptive Responses
Principles of Physiology
Biomaterials
Hormones and Behavior
Developmental Biology
Biology of Reproduction
Animal Locomotion
Toxicology
The Brain: An Introduction to Neuroscience
Area 3 (Organismal Biology)1
Diversity of Life
The Ecology and Evolution of Infectious Disease
Invertebrate Zoology
Principles of Ecology
The Evolution of Plant Diversity
Evolutionary Behavioral Ecology
Evolutionary Biology
Terrestrial Biogeochemistry and the Functioning of Ecosystems
Conservation in the Genomics Age
Animal Locomotion
Environmental Science in a Changing World
Six additional courses chosen from BIOL and/or NEUR offerings for concentrators. The Core may include up to two related sciences, with advisor approval. The Core must also include a Senior Capstone.6
SENIOR CAPSTONE: *Only apples to students who have declared in Fall 2019 or later.* To be fulfilled via ONE of the following:
1. One of the following approved courses: BIOL 1100, 1250, 1515, 1555, 1565, 1575, 1600, 1820, 1970A.
2. One semester of independent research/independent study (BIOL 1950 or BIOL 1960).
Please visit the BUE webpage for more information.
Total Credits10


Honors: Honors in biology requires a thesis and presentation based on a research project (conducted via BIOL 1950/BIOL 1960), and quality grades in the concentration. Guidelines and information on faculty research are available in the Office of Biology Undergraduate Education or found at http://www.brown.edu/academics/biology/undergraduate-education/.

Standard Program for the Sc.B. Biology

The concentration program for the Sc.B. in Biology consists of seven prerequisite courses in math, chemistry, and physics as well as fourteen courses in biological sciences, including courses in each of the following three areas: Area 1: Cell/Molecular Biology, Area 2: Structure/Function, and Area 3: Organismal Biology, and the three-course Track.  The biological sciences requirement also requires research (BIOL 1950/BIOL 1960), which should reflect the advanced cluster.

Students pursuing a ScB in Biology have the option to substitute a course for CHEM 0360 (Organic Chemistry) in their background core. For students pursuing all tracks, BIOL 0280 (Introductory Biochemistry) may serve as the replacement course.  Please note that approval from the concentration advisor is required for these background course substitutions. If the student has already declared, then a revised concentration plan must be submitted and approved via the ASK system. If BIOL 0280 is used as a substitute for CHEM 0360, it cannot be counted as a core course or as an Area 1 course. Students planning to apply to medical or graduate school should seek additional advising (such as from the Health Careers Office) in crafting their course plan.

The Biology Sc.B. Concentration Worksheet may be a useful tool for course planning.

Prerequisites: 1
Single Variable Calculus, Part I (or placement. MATH 0050/MATH 0060 may be substituted for MATH 0090)
One of the following:
Single Variable Calculus, Part II (or placement)
Single Variable Calculus, Part II (Accelerated)
or a statistics course to be approved by the concentration advisor
Each of the following:
Equilibrium, Rate, and Structure (or IB credit)
Organic Chemistry I
Organic Chemistry II
Biochemistry
Basic Physics A (or equivalent. PHYS 0050 PHYS 0070, or ENGN 0030 may be substituted for PHYS 0030.)
Basic Physics B (or equivalent. PHYS 0060 or ENGN 0040 may be substituted for PHYS 0040.)
Core Courses: 2,3,4
BIOL 0200The Foundation of Living Systems (or placement)1
Area 1 (Cell/Molecular Biology)1
Biochemistry
Genetics
Cell and Molecular Biology
Introductory Microbiology
Principles of Immunology
Biology of the Eukaryotic Cell
Developmental Biology
Conservation in the Genomics Age
21st Century Applications in Cell and Molecular Biology
Toxicology
Principles of Neurobiology
Area 2 (Structure/Function)1
Biological Design: Structural Architecture of Organisms
Invertebrate Zoology
Inquiry in Plant Biology: Analysis of Plant Growth, Reproduction and Adaptive Responses
Principles of Physiology
Biomaterials
Hormones and Behavior
Developmental Biology
Biology of Reproduction
Animal Locomotion
Toxicology
The Brain: An Introduction to Neuroscience
Area 3 (Organismal Biology)1
Diversity of Life
The Ecology and Evolution of Infectious Disease
Invertebrate Zoology
Principles of Ecology
The Evolution of Plant Diversity
Evolutionary Behavioral Ecology
Evolutionary Biology
Terrestrial Biogeochemistry and the Functioning of Ecosystems
Conservation in the Genomics Age
Animal Locomotion
Environmental Science in a Changing World
Six additional courses chosen from BIOL and/or NEUR offerings for concentrators. The Core may include up to two related sciences, with advisor approval. The Core must also include research. 46
RESEARCH:
The two semester research requirement may be satisfied by any two of the opportunities listed below. Students may find the following resources useful in planning for research: the annual BUE-PLME Finding, Securing and Succeeding in Research workshop, the BUE Research webpage, and the Sheridan Center’s Undergraduate Research & Experiential Opportunities webpage. Following conversation and agreement with the advisor, students articulate the research plan in the ASK declaration (in the designated text box) which is submitted for review and approval by the advisor.
Choose two:
Directed Research/Independent Study
Directed Research/Independent Study
Independent Study
Independent study course in a related discipline (i.e. STEM disciplines, ENVS, PHP, etc.) if the project is relevant to the student’s learning goals and interests in the concentration.
The following COEX courses: BIOL 0285, BIOL 0440, BIOL 0600, BIOL 0940G, BIOL 1515, BIOL 1555; NEUR 1630, CLPS 1195. New COEX courses will be considered as they are developed and offered at Brown, and as relevant to the concentration.
A summer research experience equivalent in scope and scale to work the student would pursue in a Biology independent study course. Examples include UTRAs, LINK awards, approved research programs at other institutions, etc. These experiences do not count as a course in the 10 course core requirement, but they can be used to satisfy the one semester of the research requirement. Advisors will work with students to review these experiences - drawing on a range of potential materials including a written summary of the experience, formal work plans, materials produced (i.e. presentations/papers), and in some cases a letter from the supporting advisor.
Other equivalent opportunities not listed - with approval from the concentration advisor and Dean Achilli.
Students are encouraged to pursue research related to their track
TRACK:
The advanced thematic track consists of three additional biological sciences courses (not including BIOL 1950/1960 research) that form a Track. Tracks include: Immuno/Pathobiology; Ecology, Evolution and Organismal Biology; Physiology and Biotechnology; Neurobiology; Physical Sciences; Cell and Molecular Biology; Biomedical Informatics. At least two track courses, and preferably all three, must be above 1000-level. Track courses should form a cohesive grouping approved by the concentration advisor.3
Biomedical Informatics - BIOL 1565 is required for this track along with 2 additional courses from the following (Additional advanced courses will be considered w/ advisor approval):
Methods in Informatics and Data Science for Health
Evaluation of Health Information Systems
Artificial Intelligence in Biomedicine
Cell and Molecular Biology
Biology of the Eukaryotic Cell
Advanced Biochemistry
Biomolecular Interactions: Health, Disease and Drug Design
Developmental Biology
Biology of Reproduction
Molecular Genetics
Human Genetics and Genomics
21st Century Applications in Cell and Molecular Biology
Environmental Health and Disease
Toxicology
Stem Cell Biology
Ecology, Evolution and Organismal Biology
Foundations of Population Genetics
Computational Methods for Studying Demographic History with Molecular Data
Coral Reef Ecology
Human Population Genomics
Conservation Biology
Terrestrial Biogeochemistry and the Functioning of Ecosystems
Conservation in the Genomics Age
Human Genetics and Genomics
Animal Locomotion
Comparative Biology of the Vertebrates
Human Anatomy and Biomechanics
Immunobiology
Host-microbiome Interactions in Health and Disease
Cancer Biology
Innate Immunity
Parasitism: Biology and Disease
Virology
Development of Vaccines to Infectious Diseases
Neurobiology
Cell Physiology and Biophysics
Topics in Signal Transduction
Synaptic Transmission and Plasticity
Physiological Pharmacology
Structure of the Nervous System
Experimental Neurobiology
NEUR listings 1000 level or above
Physiology and Biotechnology
Biotechnology and Global Health
Polymer Science for Biomaterials
Cell Physiology and Biophysics
Topics in Signal Transduction
Biomaterials
Tissue Engineering
Stem Cell Engineering
Principles of Exercise Physiology
Synaptic Transmission and Plasticity
Physiological Pharmacology
Biomolecular Interactions: Health, Disease and Drug Design
21st Century Applications in Cell and Molecular Biology
Environmental Health and Disease
Toxicology
Physical Sciences
Must be a coherent set of courses drawn from the Physical Sciences; courses must be above the introductory level and approved by advisor
Total Credits13

Honors: Honors in biology requires a thesis and presentation based on a research project (usually conducted via BIOL 1950/BIOL 1960), and quality grades in the concentration. Guidelines and information on faculty research are available in the Office of Biology Undergraduate Education or at http://www.brown.edu/academics/biology/undergraduate-education/.

Stipulations for Biology Programs:

  1. For double concentrations, no more than two courses may overlap (i.e., be used to meet requirements of both concentrations) with a few specific exceptions
  2. No more than two semesters of directed research may be used as concentration credits. Each does count as an individual core course towards the program, but only carry one lab credit or one 1000-level credit towards the three required.
  3. A limited number of transfer or study abroad courses may be used within the program, subject to approval of advisor, and Associate Dean of Biology, Toni-Marie Achilli.

Health & Human Biology

Health and Human Biology is an interdisciplinary concentration that provides a rigorous foundation in the biological sciences with substantive course work in humanities and social sciences within a subfield of Human Health and Disease. The program includes: background courses, biology core courses, a set of theme courses, and a Senior Capstone activity. Background courses provide the essential foundations in chemistry, mathematics, methods, and basic biology. These support the Biology core, which is comprised of a flexible menu of intermediate and advanced courses. A required portion of the Biology core is Genetics, a cornerstone of human biology and its interface with other fields. The Biology core underscores the related coursework within the Health and Disease Theme. The Theme courses are social science and humanities courses that form a cohesive, thoughtful grouping. Theme groupings must be approved by the advisor. A required senior capstone course or activity builds on the program's focus.

 

Program Requirements

REQUIRED BACKGROUND:
Four (4) courses including:
MATH 0090Single Variable Calculus, Part I (or equivalent placement)1
OR
Analytic Geometry and Calculus
and Analytic Geometry and Calculus
OR
Single Variable Calculus, Part II
Single Variable Calculus, Part II (Accelerated)
CHEM 0330Equilibrium, Rate, and Structure1
BIOL 0200The Foundation of Living Systems1
Statistics or methods course chosen with advisor's help.1
CORE PROGRAM:
In addition to the stated background in Chemistry, Math, Biology and Statistics, five (5) Biology plus four (4) coherently-grouped Theme courses, plus a Senior-Year Capstone course or project. (See description of Capstone at link below this table).
BIOLOGY:
Five (5) courses, including:5
Genetics, which can be fulfilled in the following ways:
Genetics
-OR-
Evolutionary Biology
and Cell and Molecular Biology
-OR-
Evolutionary Biology
and Introductory Microbiology
-OR-
Evolutionary Biology
and Biochemistry
Select one course in structure/function/development such as:
Biological Design: Structural Architecture of Organisms
Principles of Physiology
Developmental Biology
Animal Locomotion
The Brain: An Introduction to Neuroscience
One course in organismal/population biology such as:
The Ecology and Evolution of Infectious Disease
Invertebrate Zoology
Principles of Ecology
Evolutionary Biology
Conservation Biology
Methods in Informatics and Data Science for Health
Environmental Science in a Changing World
Or a course from the NEUR 1940 series
Two Biology or Neuroscience courses. At least one must be at the advanced level.
THEME: With the advisor's assistance, a theme is chosen and a cohesive set of courses are selected from outside of Biology and Neuroscience.4
No more than TWO courses from a given department may be included in the theme portion
Students will then select from FOUR theme options: 1) Mind, Brain, Behavior, 2) Planetary Health, 3) Global Health, 4) Social Determinants of Health
SENIOR CAPSTONE ACTIVITY: Must be conducted during the senior year, fulfilled by one of the following, and related to the students learning goals in the concentration:1
1) Advisor approved senior seminar or advanced course related to the theme
2) One semester of independent research/independent study (BIOL 1950 or BIOL 1960); in the case of a senior honors thesis, either BIOL 1950 or BIOL 1960 can be used as the capstone.
3) An appropriate internship with a scholarly context can be used if coupled with independent study mentored by a Brown faculty member the following semester.
Total Credits14

CAPSTONE: See https://www.brown.edu/academics/biology/undergraduate-education/undergraduate/health-and-human-biology for more information on the Capstone Activity.

HONORS:  See more information about Honors at https://www.brown.edu/academics/biology/undergraduate-education/honors-biological-sciences.

Applied Mathematics-Biology

Biology, the science of all life and living matter, is an incredibly diverse discipline offering students the opportunity to learn about topics ranging from the fundamental chemical reactions that fuel all living organisms to the population dynamics of entire ecosystems all the way to the question of how our brains give rise to the complexities of human cognition and experience. Applied mathematics is an increasingly important component of modern biological investigation. Modern technologies have enabled the creation of vast new biological data sets that often require sophisticated mathematical and statistical models for interpretation and analysis. Advances in computing have similarly enabled the simulation of biological phenomena at increasingly fine levels of detail. Entire subfields, such as bioinformatics and computational neuroscience, have developed around these new paradigms of biological investigation. The foundations of these new fields are inherently mathematical, with a focus on probability, statistical inference, and systems dynamics. 

The Applied Mathematics – Biology concentration allows students to develop complementary expertise in biology and applied mathematics. Students will focus their advanced biological coursework in an area of particular interest to them. The applied math requirements emphasize those areas of mathematics that have found widespread use throughout all of the biological sciences. The program culminates in a senior capstone experience that enables students to participate in creative research collaborations with faculty.

Standard program for the Sc.B. degree

Prerequisites – the equivalent of two semesters of single-variable calculus
Single-variable calculus is not an enforced requirement for our concentration, but it is a required prerequisite for many of our courses. At Brown, single-variable calculus consists of MATH 0090 followed by one of MATH 0100, MATH 0170, or MATH 0190.
Requirements – 16 courses 1
Mathematical Requirements – 7 courses
MATH 0180Multivariable Calculus1
or MATH 0200 Multivariable Calculus (Physics/Engineering)
or MATH 0350 Multivariable Calculus With Theory
MATH 0520Linear Algebra1
or MATH 0540 Linear Algebra With Theory
APMA 0350Applied Ordinary Differential Equations 21
APMA 0360Applied Partial Differential Equations I 31
APMA 1655Honors Statistical Inference I1
or APMA 1650 Statistical Inference I
APMA 1070Quantitative Models of Biological Systems1
APMA 1080Inference in Genomics and Molecular Biology1
or NEUR 2110 Statistical Neuroscience
Scientific Requirements – 7 courses
One approved course (or course grouping) covering Newtonian mechanics. 41
CHEM 0330Equilibrium, Rate, and Structure1
BIOL 0200The Foundation of Living Systems 51
Two approved courses in the biological sciences. All four biological electives (two here and two in the next requirement) should form a cohesive grouping in a specific area of biological interest. 62
Two approved 1000-level or higher courses in the biological sciences. All four biological electives (two here and two in the previous requirement) should form a cohesive grouping in a specific area of biological interest. 62
Additional Requirements – 2 courses
One approved course in the mathematical, biological, or computational sciences. 71
One approved capstone, senior seminar, or research-related course in the mathematical or biological sciences. 81
Total Credits16

Professional Tracks

The requirements for the professional tracks include all those of each of the standard tracks, as well as the following:

Students must complete full-time professional experiences doing work that is related to their concentration programs, totaling 2-6 months, whereby each internship must be at least one month in duration in cases where students choose to do more than one internship experience. Such work is normally done at a company, but may also be at a university under the supervision of a faculty member. Internships that take place between the end of the fall and the start of the spring semesters cannot be used to fulfill this requirement.

On completion of each professional experience, the student must write and upload to ASK a reflective essay about the experience, to be approved by the student's concentration advisor, addressing these questions:

  • Which courses were put to use in your summer's work? Which topics, in particular, were important?
  • In retrospect, which courses should you have taken before embarking on your summer experience? What are the topics from these courses that would have helped you over the summer if you had been more familiar with them?
  • Are there topics you should have been familiar with in preparation for your summer experience, but are not taught at Brown? What are these topics?
  • What did you learn from the experience that probably could not have been picked up from course work?
  • Is the sort of work you did over the summer something you would like to continue doing once you graduate? Explain.
  • Would you recommend your summer experience to other Brown students? Explain.

Honors

Concentrators that demonstrate excellence in grades and in undergraduate research can be awarded departmental honors. Honors students with primary advisors in Applied Math should follow the guidelines, requirements, and deadlines for honors as described in the bulletin for Applied Math concentrators and as published on the APMA departmental website. Honors students with primary advisors in Biomed should follow the guidelines, requirements, and deadlines for honors as described in the bulletin for Biology concentrators and as published on the Biology departmental website. Students wishing to do honors research with a non-APMA or Biomed advisor should contact the Directors of Undergraduate Studies in APMA and Biology to discuss options.

Biochemistry & Molecular Biology

How does life work at the molecular level? This question is at the core of the concentration program Biochemistry and Molecular Biology. In earlier years of this discipline, the focus was on structure and function of proteins, nucleic acids, lipids, carbohydrates and small molecules such as vitamins. Today the logical approach and tools of biochemical science are being expanded to new areas in neuroscience, developmental biology, immunology, pharmacology and synthetic biology (the design of analogs of biological systems). Training in biochemistry begins with a foundation in mathematics, physics, chemistry and biology. Some courses offered in other departments, including engineering, geology and computer science, are also useful. A key component of this program is the year of hands-on research carried out in collaboration with a faculty member here at Brown. Faculty sponsors are drawn from both the Chemistry Department and the Division of Biology and Medicine, and include basic science and clinical faculty.

 

Standard program for the Sc.B. degree

Students must take twenty courses in biology, chemistry, mathematics, and physics, including the following core requirements, some of these may be fulfilled with AP credits.

Three courses in mathematics including two courses in MATH 0090/0100 or MATH 0170/0180 with a third class in statistics, math, or computer science 13
Options for statistics courses include: 1
Essential Statistics
Statistical Inference I
Honors Statistical Inference I 3
Statistical Analysis of Biological Data
Statistical Methods
Essentials of Data Analysis
Principles of Biostatistics and Data Analysis
Two courses in physics, typically: 12
Basic Physics A
Foundations of Mechanics
Introduction to Engineering
Basic Physics B
Foundations of Electromagnetism and Modern Physics
Engineering Statics and Dynamics
Three courses in physical and organic chemistry:3
Equilibrium, Rate, and Structure
Organic Chemistry I
One course in biophysical chemistry:1
Biophysical and Bioinorganic Chemistry
Four courses in biochemistry:4
Biochemistry
Inquiry in Biochemistry: From Gene to Protein Function
Plus two of three upper level biochemistry courses:
Advanced Biochemistry
Chemical Biology
Biochemistry
The two semester research requirement may be satisfied by any two of the following. Students should discuss alternative arrangements or special situations directly with their concentration advisor to obtain prior approval.2
Directed Research/Independent Study
Directed Research/Independent Study
Undergraduate Research
Undergraduate Research - Writing Designated and Mandatory S/NC
Undergraduate Research - Writing Designated
Select biology or chemistry COEX courses (BIOL 0190R, BIOL 0190S, BIOL 0440, BIOL 0600, BIOL 0940G, CHEM 0500)
A summer research experience with faculty in Biology or Chemistry at Brown equivalent or greater in scope and scale to work the student would pursue in a Biology or Chemistry independent study course to satisfy one semester of the research requirement.
Suggested Elective Courses:
Students are required to take five courses from the chart below or, with approval from a concentration advisor, from any science or mathematics course relevant to biochemistry, cell and molecular biology. 5
Applied Mathematics Electives:
Methods of Applied Mathematics I
Mathematical Methods in the Brain Sciences
Essential Statistics
Biology Electives:
Principles of Nutrition
Techniques in Regenerative Medicine: Cells, Scaffolds and Staining
Biotechnology in Medicine
Phage Hunters, Part I
Phage Hunters, Part II
The Foundation of Living Systems
The Ecology and Evolution of Infectious Disease
Microbes in the Environment
Inquiry in Plant Biology: Analysis of Plant Growth, Reproduction and Adaptive Responses
Genetics
Cell and Molecular Biology
Introductory Microbiology
Principles of Immunology
Principles of Physiology
Biology of the Eukaryotic Cell
Polymer Science for Biomaterials
Cell Physiology and Biophysics
Topics in Signal Transduction
Biomaterials
Stem Cell Engineering
Protein Biophysics and Structure
Synthetic Biological Systems
Physiological Pharmacology
Cancer Biology
Biomolecular Interactions: Health, Disease and Drug Design
Developmental Biology
Biology of Reproduction
Innate Immunity
Molecular Genetics
Virology
Development of Vaccines to Infectious Diseases
Drug and Gene Delivery
The Biology of Aging
Chemistry Electives:
Inorganic Chemistry
Physical Chemistry: Quantum Chemistry
Physical Chemistry: Thermodynamics and Statistical Mechanics
Computational Tools in Biochemistry and Chemical Biology
Chemical Biology
Biochemistry
Advanced Organic Chemistry
Organic Reactions
Computer Science Electives:
A First Byte of Computer Science
Computing Foundations: Data
Introduction to Object-Oriented Programming and Computer Science
Introduction to Algorithms and Data Structures
Computer Science: An Integrated Introduction
Computer Science: An Integrated Introduction
Accelerated Introduction to Computer Science
Computational Molecular Biology
Engineering Electives:
Materials Science
Neuroscience Electives: 2
The Brain: An Introduction to Neuroscience
Principles of Neurobiology
Neural Systems
Introduction to Neurogenetics
Neuropharmacology and Synaptic Transmission
The Diseased Brain: Mechanisms of Neurological and Psychiatric Disorders
Physics Electives:
Introduction to Relativity, Waves and Quantum Physics
Public Health Electives:
Essentials of Data Analysis
Total Credits20

Honors Requirements for Biochemistry

All ScB Biochemistry concentrators are candidates for Honors; no separate application is necessary.

The requirements for Honors in Biochemistry are:

* Students must have a majority of either As or S with distinction grades in concentration courses. 

* Two semesters of Independent Study (CHEM 0980, CHEM 0980S, CHEM 0981,  BIOL 1950, or BIOL 1960). Guidelines and requirements associated with Independent Study are in the Undergraduate Concentration Handbook which can be found at the department website.

* A Thesis in a form approved by the research advisor, and recommended by the research advisor.  Additional information about thesis guidelines will be provided by the Concentration Advisor in the first half of the fall semester.

* An oral presentation of the thesis in a fifteen-minute senior talk followed by a five-minute question and answer period. 

Biomedical Engineering

Biomedical engineering is a dynamic and growing field based upon the application of the tools of engineering to the subject matter of biology and medicine. The undergraduate program in biomedical engineering is an independent concentration structured as a joint program between the Division of Biology and Medicine and the School of Engineering. Students can take courses from and do research with faculty from engineering, the various departments of biology, and the Brown-affiliated hospitals in Rhode Island. The Biomedical Engineering concentration shares much of the core with the other engineering programs, but the program’s primary emphasis is on the fundamentals of biomedical engineering, while also allowing students to personalize their curriculum. Biomedical engineers design new drugs, genetically engineer organisms, and devise new medical and medical instruments. They also use their understanding of biology to reinvent man-made materials and products. BME students learn to apply the principles of engineering and science, along with problem solving skills and critical thinking to a broad spectrum of engineering problems. Further, BME is a sound foundation for lifelong education with its emphasis on the use of teamwork, effective communication skills, and an understanding of broad social, ethical, economic and environmental consequences. The biomedical engineering curriculum at Brown prepares students for careers in biomedical engineering and biotechnology, as well as careers in diverse areas such as medicine, law, business, and health care delivery.

The Sc.B. program in Biomedical Engineering is accredited by the Engineering Accreditation Commission of ABET http://www.abet.org/. It is jointly offered by the School of Engineering and the Division of Biology and Medicine as an interdisciplinary concentration designed for students interested in applying the methods and tools of engineering to the subject matter of biology and the life sciences. Alumni of the Biomedical Engineering (BME) program will achieve one or more of these program educational objectives (PEOs) within five (5) years of graduation: (1) Serve society through work or advanced study in a broad range of fields including, but not limited to, medicine, healthcare, industry, government, and academia; (2) Apply their deeply creative and versatile biomedical engineering education to solve a broad spectrum of engineering and societal challenges; and (3) Contribute as role models, mentors, or leaders in their fields. The student outcomes of this program are the ABET (1) - (7) Student Outcomes as defined by the ABET Criteria for Accrediting Engineering Programs, available online at http://www.abet.org/accreditation-criteria-policies-documents/. The Biomedical Engineering concentration shares much of the core with the other engineering programs, but is structured to include more courses in biology and chemistry, and a somewhat different emphasis in mathematics.

The requirements regarding Mathematics, Advanced Placement, Transfer Credit, Substitutions for Required Courses, and Humanities and Social Science Courses are identical to those of the Sc.B. degree programs in Engineering. Please refer to the Engineering section of the University Bulletin for explicit guidelines.  

The Biomedical Engineering concentration shares much of the core with the other engineering programs, but is structured to include more courses in biology and chemistry, and a somewhat different emphasis in mathematics.

 Standard program for the Sc.B. degree

1. Core Courses
ENGN 0030Introduction to Engineering1
or ENGN 0031 Honors Introduction to Engineering
or ENGN 0032 Introduction to Engineering: Design
ENGN 0040Engineering Statics and Dynamics1
ENGN 0510Electricity and Magnetism1
or ENGN 0520 Electrical Circuits and Signals
ENGN 0720Thermodynamics1
ENGN 0810Fluid Mechanics1
CHEM 0330Equilibrium, Rate, and Structure1
MATH 0190Single Variable Calculus, Part II (Physics/Engineering)1
or MATH 0100 Single Variable Calculus, Part II
CHEM 0350Organic Chemistry I1
MATH 0200Multivariable Calculus (Physics/Engineering)1
or MATH 0180 Multivariable Calculus
or MATH 0350 Multivariable Calculus With Theory
APMA 0350Applied Ordinary Differential Equations 11
APMA 1650Statistical Inference I1
or BIOL 0495 Statistical Analysis of Biological Data
or PHP 1510 Principles of Biostatistics and Data Analysis
or APMA 1655 Honors Statistical Inference I
2. Upper Level Biomedical Engineering Curriculum
ENGN 1110Transport and Biotransport Processes1
ENGN 1210Biomechanics1
ENGN 1230Instrumentation Design1
ENGN 1490Biomaterials1
BIOL 0800Principles of Physiology1
3. Additional Biomedical Engineering Electives: Complete at least 3 courses from the following groups; other upper-level courses are subject to Concentration Advisor approval.3
Select one or two of the following:
Computational Molecular Biology
Algorithmic Foundations of Computational Biology
Digital Computing Systems
Neuroengineering
Nanoengineering and Nanomedicine
Cardiovascular Engineering
Recent Advances in Biomedical Engineering
Computer Aided Visualization and Design
Biomedical Optics
Optical Microscopy: Fundamentals and Applications
Cancer Nanotechnology
Analytical Modeling for Biomechanical and Biomedical Systems
Implantable Devices
Tissue Engineering
Stem Cell Engineering
Drug and Gene Delivery
At least one or two more courses from:
Biochemistry
Genetics
Cell and Molecular Biology
Introductory Microbiology
Principles of Immunology
Polymer Science for Biomaterials
Cell Physiology and Biophysics
Methods in Informatics and Data Science for Health
Quantitative Models of Biological Systems
Organic Chemistry II
Topics in Translational Research and Technologies
Principles of Neurobiology
Mechanisms and Meaning of Neural Dynamics
Biological Physics
21st Century Applications in Cell and Molecular Biology
4. Capstone Design 2
ENGN 1930LBiomedical Engineering Design and Innovation 11
ENGN 1931LBiomedical Engineering Design and Innovation II 11
5. General Education Requirement: At least four approved courses must be taken in the humanities and social sciences.
Total Credits21

Biophysics

Biophysics is a quantitative science at the intersection of the life and physical sciences.  It requires a significant level of competence in physics, chemistry, biology and math as reflected in the concentration requirements.  Students should work with their concentration advisor to develop a focused academic plan that complements the required research component of the concentration and allows students to develop analytical and quantitative skills.  

Student Goals:
Students in this concentration will:

  • Explore the relationship between biological and physical principles by successfully completing foundational courses in biology, physics, math and chemistry
  • Gain an in-depth knowledge of the interdisciplinary nature of life and physical sciences by selecting and successfully completing advanced courses in biology, physics, math, chemistry or related fields 
  • Develop skills to identify and analyze critical questions central to biophysics
  • Apply quantitative methods to problems at the interface of life and physical sciences 
  • Complete a research project with a faculty advisor that focuses on a particular theme or problem in the field of biophysics where students apply knowledge gained throughout the curriculum.

Additional detailed information about the field of Biophysics may be found at: https://www.brown.edu/academics/biology/undergraduate-education/undergraduate/biophysics

Standard program for the Sc.B. degree

Requirements

Physics
One of the following series: 2
Basic Physics A
and Basic Physics B 1
Foundations of Mechanics
and Foundations of Electromagnetism and Modern Physics
Analytical Mechanics
and Introduction to Relativity, Waves and Quantum Physics
PHYS 0470Electricity and Magnetism1
Chemisty
CHEM 0330Equilibrium, Rate, and Structure1
CHEM 0350Organic Chemistry I1
Select one other advanced Chemistry Course1
Math
MATH 0090Single Variable Calculus, Part I (or equivalent)1
MATH 0100Single Variable Calculus, Part II (or equivalent)1
MATH 0180Multivariable Calculus (or equivalent)1
Biology
BIOL 0200The Foundation of Living Systems (or equivalent)1
Select four additional biology or neuroscience courses chosen with approval of the advisor. 4
Directed Research: Students must take two semesters of research which may be satisfied by any of the opportunities listed below:2
Directed Research in Biology (BIOL 1950/BIOL 1960), Chemistry (CHEM 0970/CHEM 0980), or Physics (PHYS 1980)
COEX courses
A summer research experience in equivalent scope and scale to an independent study, but this would not count as course credit toward the concentration
Electives: Four electives in biology, physics, math/applied math, chemistry, neuroscience, engineering or computer science; at least 2 courses must be above the introductory level 24
Total Credits20

Computational Biology

Computational biology involves the analysis and discovery of biological phenomena using computational tools, and the algorithmic design and analysis of such tools. The field is widely defined and includes foundations in computer science, applied mathematics, statistics, biochemistry, molecular biology, genetics, ecology, evolution, anatomy, neuroscience, and visualization. 

Students may pursue a Bachelor of Arts or a Bachelor of Science. Students pursuing the ScB have the option of electing a concentration in Computational Biology with one of three focus areas: Computer Sciences, Biological Sciences, or Applied Mathematics & Statistics. Both programs require a senior capstone experience that pairs students and faculty in creative research collaborations.

Standard program for the A.B. degree

Please see the bottom of the page for more information regarding the University Writing Requirement, the Capstone Experience, and the Computational Biology Honors Program. 

Prerequisites:2
Single Variable Calculus, Part II
Single Variable Calculus, Part II (Accelerated)
The Foundation of Living Systems
General Core Requirements: Biology2
Genetics
Biochemistry
Cell and Molecular Biology
General Core Requirements: Chemistry1
Equilibrium, Rate, and Structure
Organic Chemistry I
General Core Requirements: Computer Science2-3
Choose one of the following groupings of introductory courses:
Group A
Computing Foundations: Data
and Computing Foundations: Program Organization
and Program Design with Data Structures and Algorithms 1
Group B
Introduction to Object-Oriented Programming and Computer Science
and Program Design with Data Structures and Algorithms
Group C
Computer Science: An Integrated Introduction
and Program Design with Data Structures and Algorithms
Group D
Accelerated Introduction to Computer Science (and any full-credit computer science course above CSCI 0190)
General Core Requirements: Probability & Statistics1
Statistical Inference I
OR
Advanced Introduction to Probability for Computing and Data Science
OR
Probability
Comp Bio Core Course Requirements4
Computational Molecular Biology
Inference in Genomics and Molecular Biology
AND two of the following:
Statistical Inference II
Computational Probability and Statistics
Foundations of Population Genetics
Computational Methods for Studying Demographic History with Molecular Data
Human Population Genomics
Methods in Informatics and Data Science for Health
Machine Learning
Deep Learning
Algorithmic Foundations of Computational Biology
Additional course with Director approval
Capstone Experience
Students enrolled in the computational biology concentration will complete a research project in their senior year under faculty supervision (i.e: BIOL 1950/1960, CSCI 1970, APMA 1970). The themes of such projects evolve with the field and the technology, but should represent a synthesis of the various specialties of the program. The requirements are either one semester of reading and research with a CCMB Faculty member or approved advisor, or a 2000-level Computational Biology course.
Total Credits12-13

Standard program for the Sc.B. degree

Please see the bottom of the page for more information regarding the University Writing Requirement, the Capstone Experience, and the Computational Biology Honors Program.  

Prerequisites2
Single Variable Calculus, Part II (or equivalent)
Single Variable Calculus, Part II (Accelerated)
The Foundation of Living Systems (or equivalent)
General Core Course Requirements: Biology2
Genetics (prerequisite BIOL 0200 or equivalent)
Biochemistry
Cell and Molecular Biology
General Core Requirements: Chemisty1
Equilibrium, Rate, and Structure
Organic Chemistry I
General Core Requirements: Computer Science3-4
Introduction to Discrete Structures and Probability
AND complete one of the following groupings of introductory courses:
Group A
Computing Foundations: Data
and Computing Foundations: Program Organization
and Program Design with Data Structures and Algorithms 1
Group B
Introduction to Object-Oriented Programming and Computer Science
and Program Design with Data Structures and Algorithms
Group C
Computer Science: An Integrated Introduction
and Program Design with Data Structures and Algorithms
Group D
Accelerated Introduction to Computer Science (and any full-credit computer science course above CSCI 0190.)
General Core Requirements: Probability & Statistics1
Statistical Inference I
Advanced Introduction to Probability for Computing and Data Science
Probability
General Core Requirements: Computational Biology
CSCI 1810Computational Molecular Biology1
APMA 1080Inference in Genomics and Molecular Biology1
Capstone Experience1
Students enrolled in the computational biology concentration will complete a research project in their senior year under faculty supervision (i.e: BIOL 1950/1960, CSCI 1970, APMA 1970). The themes of such projects evolve with the field and the technology, but should represent a synthesis of the various specialties of the program. The requirements are either one semester of reading and research with a CCMB Faculty member or approved advisor, or a 2000-level Computational Biology course.
Six Courses in one of the following 3 tracks6
Computer Science Track:
Three of the following:
Introduction to Computer Graphics
Database Management Systems
Artificial Intelligence
Machine Learning
Deep Learning
Probabilistic Methods in Computer Science
Design and Analysis of Algorithms
or other Computer Science courses approved by the concentration advisor.
AND three of the following:
Statistical Inference II
Computational Probability and Statistics
Foundations of Population Genetics
Computational Methods for Studying Demographic History with Molecular Data
Human Population Genomics
Introduction to Software Engineering
and Introduction to Computer Systems
Algorithmic Foundations of Computational Biology
Statistical Methods in Bioinformatics, I
Biological Sciences track
At least four courses comprising a coherent theme in one of the following areas: Biochemistry, Ecology, Evolution, or Neurobiology.
AND two courses from the following:
Statistical Inference II
Computational Probability and Statistics
Foundations of Population Genetics
Computational Methods for Studying Demographic History with Molecular Data
Human Population Genomics
Machine Learning
Deep Learning
Algorithmic Foundations of Computational Biology
Statistical Methods in Bioinformatics, I
Applied Mathematics & Statistics Track:
At least three courses from the following:
Statistical Inference II
Computational Probability and Statistics
Artificial Intelligence
Methods of Applied Mathematics I
and Methods of Applied Mathematics II
Applied Ordinary Differential Equations
and Applied Partial Differential Equations I
At least three of the following:
Quantitative Models of Biological Systems
Foundations of Population Genetics
Computational Methods for Studying Demographic History with Molecular Data
Human Population Genomics
Machine Learning
Deep Learning
Algorithmic Foundations of Computational Biology
Statistical Methods in Bioinformatics, I
Total Credits18-19

University Writing Requirement:

As part of Brown’s writing requirement, all students must demonstrate that they have worked on their writing both in their general studies and their concentration. There are a number of ways for Computational Biology concentrators to fulfill these requirements:

Capstone Experience:

Students enrolled in the computational biology concentration will complete a research project in their senior year under faculty supervision.  The themes of such projects evolve with the field and the technology, but should represent a synthesis of the various specialties of the program. The requirements are either one semester of reading and research with a CCMB Faculty member or approved advisor, or a 2000-level Computational Biology course.

Honors:

 In order to be considered a candidate for honors, students will be expected to maintain an outstanding record, with no "C's" in concentration courses and with a minimum of an "A-" average in concentration courses. In addition, students should take at least one semester, and are strongly encouraged to take 2 semesters, of reading and research with a CCMB faculty member or approved advisor. Students must submit to a public defense of their theses to be open to the CCMB community.

  • Students seeking honors are advised to choose a Thesis Advisor prior to the end of their Junior year
  • Students must complete the Registration form for Comp Bio and submit it to CCMB@BROWN.EDU

Any deviation from these rules must be approved by the director of undergraduate studies, in consultation with the student's advisor.